Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Palma De Mallorca, Valencia, La Spezia, Civitavecchia, Savona
2026 Sails: Apr 26, May 3, May 10, More...

MSC Cruises, MSC Musica

Deal link -> Special

7 Night - Mediterranean
Starting in Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy
2026 Sails: Apr 26, May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 12, Jul 19, Jul 26, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, More...

Viking Ocean, Viking Sea

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Apr 26, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Dubrovnik, Croatia, Split, Croatia, Trieste, Italy
2026 Sails: Apr 27, More...

MSC Cruises, MSC Splendida

8 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Palma De Mallorca (Balearic Islands), Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Apr 27, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Apr 27, May 4, May 11, May 18, May 25, Jun 1, Jun 8, Jun 15, Jun 22, Jun 29, Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, More...

Viking Ocean, Viking Mars

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Apr 27, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Venice (Chioggia), Split, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Ionian Sea, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Barcelona
2026 Sails: Apr 27, Aug 31, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, More...

MSC Cruises, MSC Seaview

4 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Apr 28, More...

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