Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

MSC Cruises, MSC Opera

3 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: May 3, More...

MSC Cruises, MSC Opera

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Gibraltar, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: May 3, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Gibraltar, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: May 3, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, More...

Norwegian Cruise Line, Norwegian Pearl

7 Night - Europe - Greek Isles - Venice
Starting in Venice (Ravenna), Italy, Montenegro, Kotor, Montenegro, Corfu, Greece, Olympia / Katakolon, Greece, Mykonos, Greece, Santorini Island, Greece, Piraeus / Athens, Greece
2026 Sails: May 3, More...

Royal Caribbean, Odyssey of the Seas

Deal link -> Special

7 Night - Greek Isles Cruise
Starting in Rome (Civitavecchia), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, More...

Uniworld Tours, S.S. La Venezia Tours

16 Night - Cruise & Rail : Venice, Istanbul & the Balkans
Starting in Venice, Venice (Padua), Mazzorbo (Burano), Mazzorbo, Burano, Chioggia, Chioggia, Chioggia, Venice, Venice, Venice, Transfer to Train, Trieste, Postojna, Ljubljana, Sarajevo, Mostar, Belgrade, Podgorica, Skopje, Sofia, Plovdiv, Istanbul
2026 Sails: May 3, Aug 23, Sep 27, More...

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Ephesus (Kusadasi), Turkey, Istanbul, Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 4, Jun 15, Aug 17, Oct 19, 2027: May 24, Jul 5, Aug 16, Sep 27, More...

Costa Cruise Lines, Costa Favolosa

13 Night - Transatlantic from Savona
Starting in Savona, Marseille, Barcelona, Malaga, Cadice, Lisbon, Leixoes, La Coruna, Le Havre, Dover UK, Hamburg
2026 Sails: May 4, More...

Costa Cruise Lines, Costa Favolosa

2 Night - Europe from Savona to Barcelona
Starting in Savona, Marseille, Barcelona
2026 Sails: May 4, More...

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