Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Viking Ocean, Viking Jupiter

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Apr 8, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 14, Oct 12, Oct 19, Oct 29, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Tunis Gulf, Palermo (Sicily)
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 7, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Genoa, Marseille, Barcelona, Cagliari, Napoli, Civitavecchia
2026 Sails: Apr 9, Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, More...

Viking Ocean, Viking Star

9 Night - Empires of the Mediterranean
Starting in Venice (Fusina), Koper, Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Santorini (Thira), Athens (Piraeus)
2026 Sails: Apr 9, Aug 13, 2027: Sep 22, 2028: Jun 14, Aug 10, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, More...

Costa Cruise Lines, Costa Toscana

5 Night - Western Mediterranean from Genova
Starting in Genoa, Marseille, Barcelona, Cagliari, Napoli
2026 Sails: Apr 10, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa, Marseille, Barcelona, Cagliari, Napoli, Civitavecchia, Genoa
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy
2026 Sails: Apr 10, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, More...

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