Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Sinfonia

5 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Civitavecchia (Rome), Italy
2026 Sails: Oct 24, More...

Royal Caribbean, Explorer of the Seas

7 Night - Italy & France Cruise
Starting in Ravenna, Italy, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy, Ajaccio, Corsica, France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Oct 24, More...

Royal Caribbean, Odyssey of the Seas

14 Night - Spain & Portugal Transatlantic
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Barcelona, Spain, Cartagena ES, Lisbon, Portugal, Ponta Delgada, Azores, Cape Liberty, Nj (Ny Metro)
2026 Sails: Oct 25, More...

Windstar, Wind Surf

5 Night - Quick Getaways : Yachtsman's Harbors of the Rivieras
Starting in Civitavecchia, Rome, Portofino, Monte Carlo, Sanary-sur-mer, Palamos, Barcelona
2026 Sails: Oct 25, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 26, Nov 2, Nov 9, Nov 16, Nov 23, Nov 30, Dec 7, Dec 14, Dec 21, Dec 28, 2027: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, More...

MSC Cruises, MSC Grandiosa

18 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida
2026 Sails: Oct 26, More...

MSC Cruises, MSC Grandiosa

19 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Funchal (Madeira Islands), Portugal, San Juan, Puerto Rico, Miami, Florida, Port Canaveral (Orlando), Florida
2026 Sails: Oct 26, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy & France Cruise
Starting in Ravenna, Italy, Amalfi Coast (Salerno), Italy, Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Ajaccio, Corsica, France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Oct 26, More...

Emerald Cruises, Emerald Azzurra

11 Night - Mediterranean Rivieras
Starting in Civitavecchia (Rome), Italy, Livorno, Italy, Ajaccio, Corsica, France, Palma De Mallorca, Spain, Cartagena ES, Malaga, Spain, Tangier, Morocco / Seville, Spain, Seville, Spain, Lisbon, Portugal
2026 Sails: Oct 27, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Oct 27, Nov 3, Nov 10, Nov 17, Nov 24, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, More...

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