Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Viking Ocean, Viking Mars

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Apr 27, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Venice (Chioggia), Split, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Ionian Sea, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Barcelona
2026 Sails: Apr 27, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 16, Jun 23, Jun 30, Jul 14, Jul 21, Jul 28, Aug 11, Aug 18, Aug 25, Sep 1, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, More...

MSC Cruises, MSC Seaview

4 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Apr 28, More...

MSC Cruises, MSC Seaview

2 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Barcelona, Spain
2026 Sails: Apr 28, More...

MSC Cruises, MSC Seaview

3 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Barcelona, Spain, Marseille (Provence), France
2026 Sails: Apr 28, More...

MSC Cruises, MSC Splendida

8 Night - Mediterranean
Starting in Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Palma De Mallorca (Balearic Islands), Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy
2026 Sails: Apr 28, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy
2026 Sails: Apr 28, May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, More...

Oceania Cruises, Oceania Marina

14 Night - Rivieras, Minarets & More
Starting in Rome (Civitavecchia), Cinque Terre (La Spezia), Saint-Tropez, Barcelona, Malaga, Seville (Cadiz), Casablanca, Agadir, Arrecife (Lanzarote), Santa Cruz de Tenerife, Santa Cruz de La Palma, Funchal (Madeira), Lisbon
2026 Sails: Apr 28, More...

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