Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Windstar, Wind Star

8 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Ponza, Sorrento, Amalfi, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2026 Sails: Apr 24, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Kotor, Montenegro, Corfu, Montenegro, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: Apr 25, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Palma De Mallorca, Valencia, La Spezia (Florence), Civitavecchia (Rome)
2026 Sails: Apr 25, May 2, May 9, More...

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Aegean
Starting in Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy
2026 Sails: Apr 25, May 26, Jun 9, Jul 7, Jul 21, Aug 18, Sep 1, Oct 13, Nov 10, 2027: Jun 12, Jun 26, Jul 10, Aug 7, Nov 6, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Palma De Mallorca, Valencia, La Spezia (Florence), Civitavecchia (Rome), Savona
2026 Sails: Apr 26, May 3, May 10, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy
2026 Sails: Apr 26, May 3, May 10, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 12, Jul 19, Jul 26, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, More...

Viking Ocean, Viking Sea

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Apr 26, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Brindisi, Italy, Dubrovnik, Croatia, Split, Croatia, Trieste, Italy
2026 Sails: Apr 27, More...

MSC Cruises, MSC Splendida

8 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Palma De Mallorca (Balearic Islands), Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Apr 27, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Apr 27, May 4, May 11, May 18, May 25, Jun 1, Jun 8, Jun 15, Jun 22, Jun 29, Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, More...

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