Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Cunard Line, Queen Victoria

14 Night - Spain, Italy and Adriatic
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Jun 1, More...

Cunard Line, Queen Victoria

7 Night - Greece and Adriatic
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Jun 1, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote D Azur), France, Genoa (Portofino), Italy
2026 Sails: Jun 1, Jun 8, Jun 15, Jun 22, Jun 29, Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Jun 1, Jun 8, Jun 15, Jun 22, Jun 29, Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, Oct 19, Oct 26, More...

Ritz-Carlton, Ilma

9 Night - Venice / Rome (Civitavecchia)
Starting in Venice, Trieste, Opatija, Split, Kotor, Dubrovnik, Croatia, Taormina (Naxos), Sicily, Sorrento, Rome (Civitavecchia)
2026 Sails: Jun 1, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Italian Riviera & France
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Florence / Pisa (La Spezia), Italy, Portofino, Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Jun 2, More...

Explora Journeys, EXPLORA I

7 Night - Race Weekend, Reimagined : F1 Grand Prix De Monaco
Starting in Civitavecchia (Rome), Monte Carlo, Civitavecchia (Rome)
2026 Sails: Jun 2, More...

Explora Journeys, EXPLORA I

13 Night - An Extended Journey to Mediterranean Icons and Formula 1 Celebrations
Starting in Civitavecchia (Rome), Monte Carlo, Civitavecchia (Rome), Sorrento, Giardini Naxos, La Valletta, Palma De Mallorca, Barcelona
2026 Sails: Jun 2, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Jun 2, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 13, Oct 20, Oct 27, Nov 3, More...

PONANT, Le Boreal

8 Night - Shores of the Adriatic
Starting in Venice, Ancona, Hvar, Dubrovnik, Croatia, Split, Zadar, Rovinj, Piran, Venice
2026 Sails: Jun 3, More...

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