Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Croatia & Malta Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Valletta, Malta, Dubrovnik, Croatia, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 19, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Oct 20, Oct 27, Nov 3, More...

Princess Cruises, Enchanted Princess

11 Night - Mediterranean with Greek Isles & Italy
Starting in Civitavecchia (for Rome), Italy, Sardinia (Alghero), Italy, Genoa (for Cinque Terre), Italy, Livorno (for Florence / Pisa), Italy, Valletta, Malta, Sicily (Messina), Italy, Mykonos, Greece, Rhodes, Greece, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece
2026 Sails: Oct 20, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Cagliari
Starting in Cagliari, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona, Cagliari
2026 Sails: Oct 21, Oct 28, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 21, More...

MSC Cruises, MSC Orchestra

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Catania, Italy, Corfu, Greece, Kotor, Montenegro, Bari, Italy
2026 Sails: Oct 21, More...

MSC Cruises, MSC Orchestra

3 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain
2026 Sails: Oct 21, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Oct 22, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Cagliari, Italy, Palermo (Sicily)
2026 Sails: Oct 22, Oct 29, More...

MSC Cruises, MSC Euribia

4 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 22, More...

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