Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Star Clippers, Star Clipper

16 Night - Grand Voyage : Rome to Venice
Starting in Civitavecchia (Port for Rome), Italy, Amalfi, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Ponza / Pontine Islands, Italy, Amalfi, Italy, Lipari / Aeolian Islands, Italy, Taormina, Sicily, Italy, Crotone, Italy, Otranto, Italy, Monopoli, Italy, Barletta, Italy, Rovinj, Croatia, Venice, Italy
2026 Sails: Jul 13, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Jul 14, Jul 21, Jul 28, Aug 11, Aug 18, Aug 25, Sep 1, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy
2026 Sails: Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, Oct 27, More...

Viking Ocean, Viking Sea

7 Night - Italian Sojourn
Starting in Venice (Fusina), Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: Jul 14, More...

Celebrity Cruises, Celebrity Ascent

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Dubrovnik, Croatia, Split, Croatia, Montenegro, Corfu, Greece, Olympia (Katakolon), Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Jul 17, Oct 9, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice)
2026 Sails: Jul 18, Aug 8, More...

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice)
2026 Sails: Jul 18, More...

MSC Cruises, MSC Meraviglia

Deal link -> Special

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: Jul 18, Jul 25, Aug 1, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

Ritz-Carlton, Ilma

6 Night - Venice / Rome (Civitavecchia)
Starting in Venice, Zadar, Dubrovnik, Croatia, Kotor, Sorrento, Rome (Civitavecchia)
2026 Sails: Jul 18, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Adriatic Cruise
Starting in Ravenna, Italy, Bay of Kotor (Cruising), Kotor, Montenegro, Athens (Piraeus), Greece, Santorini, Greece, Zadar, Croatia, Ravenna, Italy
2026 Sails: Jul 18, Sep 12, More...

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