Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Magnifica

4 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Genoa (Portofino), Italy
2026 Sails: Oct 17, Oct 21, Oct 25, 2028: Apr 29, More...

MSC Cruises, MSC Magnifica

1 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France
2026 Sails: Oct 17, 2027: Oct 20, More...

Regent Seven Seas, Seven Seas Voyager

7 Night - Mediterranean Discovery
Starting in Venice (Fusina), Rijeka, Split, Kotor, Cruising the Ionian Sea, Gythion, Mykonos, Athens (Piraeus)
2026 Sails: Oct 17, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Croatia Cruise
Starting in Ravenna, Italy, Dubrovnik, Croatia, Santorini, Greece, Athens (Piraeus), Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 17, More...

SeaDream Yacht Club, SeaDream I

7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Porto Cervo, Sardinia, Positano, Amalfi, Lipari, Aeolian Islands, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Oct 17, More...

Costa Cruise Lines, Costa Diadema

11 Night - Western Mediterranean from Savona
Starting in Savona, Italy, Barcelona, Spain, Cadiz, Spain, Lisbon, Portugal, Gibraltar (UK), Malaga, Spain, Cartagena ES, Spain, Marseille, France, Savona, Italy
2026 Sails: Oct 18, More...

MSC Cruises, MSC Meraviglia

24 Night - MSC Grand Voyages
Starting in Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Alicante, Spain, Gibraltar, Cadice (Seville), Spain, Casablanca (Marrakech), Morocco, Las Palmas De Gran Canaria, Canary Islands, Funchal (Madeira), Portugal, Ponta Delgada (Azores), Portugal, Boston, New York, Miami
2026 Sails: Oct 18, More...

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Ephesus (Kusadasi), Turkey, Istanbul, Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Oct 19, 2027: May 24, Aug 16, Sep 27, More...

Celebrity Cruises, Celebrity Eclipse

11 Night - Adriatic & Greek Isles Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Valletta, Malta, Mykonos, Greece, Santorini, Greece, Rhodes, Greece, Athens (Piraeus), Greece
2026 Sails: Oct 19, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 19, More...

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