Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Crystal Cruises, Crystal Serenity

23 Night - South America
Starting in Valparaiso, Coquimbo, Iquique, Pisco, Lima (Callao), Salaverry, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Puerto Limon, Roatan Island, Santo Tomas, Belize City, Cozumel, Quintana Roo, Progreso (Merida), Fort Lauderdale
2027 Sails: Nov 29, More...

Viking Ocean, Viking Mars

10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Merida (Progreso), Sail the Caribbean Sea, Fort Lauderdale, Florida
2027 Sails: Nov 29, 2028: Jan 16, More...

Windstar, Star Pride

7 Night - The Spanish Main : Rise of the New World
Starting in San Juan, Isla Catalina, Santo Domingo, Cartagena CO, San Blas, Panama, Colon
2027 Sails: Nov 29, More...

Windstar, Star Pride

14 Night - Star Collector : Coffee, Canal & Callaloo : Central America, Colombia & the Caribbean
Starting in San Juan, Isla Catalina, Santo Domingo, Cartagena CO, San Blas, Panama, Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Nov 29, More...

Explora Journeys, EXPLORA II

10 Night - A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities
Starting in Miami, Port Antonio, Colon, Bocas del Toro, Puerto Limon, San Andres Island, Miami
2027 Sails: Dec 2, More...

PONANT, Le Bougainville

10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2027 Sails: Dec 2, More...

Princess Cruises, Caribbean Princess

12 Night - Southern Caribbean with Panama
Starting in Fort Lauderdale, Florida, Amber Cove, Dominican Republic, Aruba, Cartagena CO, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2027 Sails: Dec 2, More...

Carnival Cruise Lines, Carnival Spirit

8 Night - Caribbean & Panama
Starting in Tampa, Fl, Limon, Costa Rica, Colon (Panama Canal), Panama, Grand Cayman, Cayman Islands, Tampa, Fl
2027 Sails: Dec 4, Dec 18, 2028: Feb 26, Mar 25, More...

Royal Caribbean, Grandeur of the Seas

7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2027 Sails: Dec 5, Dec 12, Dec 26, 2028: Jan 30, Feb 6, Feb 13, Mar 12, Mar 26, More...

Oceania Cruises, Oceania Sonata

Deal link -> Special

29 Night - Holiday Harbors & Hollywood
Starting in Miami, Oranjestad, Willemstad AN, Kralendijk, St Georges, Bridgetown, Castries, Pointe-a-Pitre, Tortola, Miami, George Town, Cartagena CO, Panama Canal Daylight Transit, Puntarenas, Puerto Quetzal, Zihuatanejo (Ixtapa), Manzanillo, Ensenada, Los Angeles
2027 Sails: Dec 6, More...

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