Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Royal Caribbean, Grandeur of the Seas

7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama, Cartagena CO
2027 Sails: Feb 14, More...

Windstar, Star Legend

14 Night - Star Collector : Windward Islands & Spanish New World
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad, Willemstad AN, Kralendijk, St Georges, Rodney Bay, The Pitons, Mayreau, Bequia, Bridgetown
2027 Sails: Feb 16, More...

Windstar, Star Legend

6 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2027 Sails: Feb 16, More...

Azamara Cruises, Azamara Journey

40 Night - Buenos Aires to Miami Grand Voyage
Starting in Buenos Aires, Montevideo, Punta Del Este, Port Stanley, Falkland Islands, Sailing the Antarctic Peninsula, Ushuaia, Sailing in the Beagle Channel, Ushuaia, Punta Arenas, Sailing in the Chilean Fjords, Puerto Chacabuco, Puerto Montt, San Antonio Cl, Coquimbo, Iquique, Arica, Pisco, Callao (Lima), Panama City (Fuerte Amador), Panama Canal (Cruising), Puerto Limon, Isla San Andres, Cozumel, Mexico, Miami, Florida
2027 Sails: Feb 17, More...

Holland America, Nieuw Amsterdam

21 Night - Southern Caribbean & Panama Canal : Abc Islands
Starting in Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2027 Sails: Feb 19, More...

PONANT, Le Laperouse

7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian Journeys
Starting in Puntarenas, Quepos, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Crossing the Panama Canal, San Blas Islands, Colon
2027 Sails: Feb 19, More...

Regent Seven Seas, Seven Seas Prestige

11 Night - Crescent Beaches & Colorful Towns
Starting in Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Cozumel, Mexico, George Town, Montego Bay, Cruising the Straits of Florida, Miami
2027 Sails: Feb 22, More...

Regent Seven Seas, Seven Seas Grandeur

14 Night - Exotic Coasts & Casco Viejo
Starting in Miami, Cruising the Straits of Florida, Costa Maya, Mexico, Harvest Caye, Roatan, Cruising the Caribbean Sea, George Town, Ocho Rios, Jamaica, Cruising the Caribbean Sea, Puerto Limon, Cruising the Caribbean Sea, Cartagena CO, Colon, Panama Canal Transit, Panama City
2027 Sails: Feb 23, More...

MSC Cruises, MSC Poesia

21 Night - Caribbean and Antilles
Starting in Miami, Florida, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Cabo Rojo, Dominican Republic, Ocho Rios, Jamaica, Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2027 Sails: Feb 25, More...

Crystal Cruises, Crystal Symphony

10 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Colon, Puerto Limon, Roatan Island, Belize City, Cozumel, Quintana Roo, Fort Lauderdale
2027 Sails: Feb 26, More...

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