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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Barro Colorado Island : Bocas del Toro : Cayos Limones : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

MSC Cruises, MSC Poesia
MSC Poesia22 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida, Montego Bay, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Dec 23, More...
MSC Cruises, MSC Poesia
MSC Poesia11 Night - Caribbean and Antilles
Starting in Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Roatan Island, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Dec 23, More...
Windstar Tours, Star Legend Tours
Star Legend Tours12 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Puerto Caldera, Punta Leona, Costa Rica, Quepos, Golfo Dulce (Puerto Jimenez), Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Dec 24, More...
Star Clippers, Star Clipper
Star Clipper7 Night - Costa Rica & Panama
Starting in Puerto Caldera, Costa Rica, Quepos, Costa Rica, Golfito, Costa Rica, Coiba National Park, Panama, Marine Park Golfo De Chiriqui / Parida Island, Panama, Islas Tortugas, Costa Rica, Puerto Caldera, Costa Rica
2026 Sails: Dec 26, 2027: Jan 2, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam21 Night - Panama Canal & Southern Caribbean Holiday
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Dec 27, More...
Windstar, Star Legend
Star Legend8 Night - Costa Rica & Panama Canal
Starting in Puerto Caldera, Punta Leona, Costa Rica, Quepos, Golfo Dulce (Puerto Jimenez), Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Dec 28, More...
Windstar Tours, Star Legend Tours
Star Legend Tours13 Night - Costa Rica, Panama Canal & Machu Picchu Cruise Tour
Starting in Puerto Caldera, Punta Leona, Costa Rica, Quepos, Golfo Dulce (Puerto Jimenez), Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Dec 28, More...
Regent Seven Seas, Seven Seas Grandeur
Seven Seas Grandeur16 Night - Panama Canal & Pacific Gems
Starting in Miami, Cruising the Straits of Florida, George Town, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Quetzal, Cruising the Pacific Ocean, Acapulco, Cruising the Pacific Ocean, Cabo San Lucas, Cruising the Pacific Ocean, San Diego, Los Angeles
2026 Sails: Dec 29, More...
Windstar Tours, Star Legend Tours
Star Legend Tours12 Night - Costa Rica, Panama Canal & Machu Picchu Cruise Tour
Starting in Lima, Peru, Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 31, 2027: Jan 14, Jan 28, More...
Holland America, Zuiderdam
Zuiderdam14 Night - Panama Canal
Starting in Miami, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Puerto Quetzal, Guatemala, Huatulco, Mexico, Acapulco, Guerrero, Mexico, Cabo San Lucas, Mexico, San Diego, California
2027 Sails: Jan 2, More...

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Panama Cruises