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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Barro Colorado Island : Bocas del Toro : Cayos Limones : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Windstar, Star Legend
Star Legend8 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Oranjestad, Cartagena CO, Bocas del Toro, San Blas, Panama, Panama Canal, Balboa / Fuerte Amador
2026 Sails: Dec 12, More...
Windstar, Star Legend
Star Legend16 Night - Star Collector : Latin America Explorer
Starting in Oranjestad, Cartagena CO, Bocas del Toro, San Blas, Panama, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 12, More...
Windstar, Wind Star
Wind Star7 Night - Costa Rica & Panama Canal
Starting in Puerto Caldera, Quepos, Golfo Dulce (Puerto Jimenez), Isla Partida, Balboa / Fuerte Amador, Panama Canal, Colon
2026 Sails: Dec 12, Dec 26, 2027: Jan 24, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Balboa / Embark Ship, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Portobelo, Colon / Disembark Ship / Panama City, Panama
2026 Sails: Dec 13, 2027: Jan 29, Nov 5, 2028: Jan 29, Mar 16, More...
MSC Cruises, MSC Poesia
MSC Poesia21 Night - Caribbean and Antilles
Starting in Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize City, Belize, Miami, Florida
2026 Sails: Dec 13, More...
Viking Ocean, Viking Mars
Viking Mars10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
Azamara Cruises, Azamara Quest
Azamara Quest18 Night - Panama Canal Cruise : Miami, Cabo Rojo & San Diego
Starting in Miami, Florida, Cabo Rojo, Cartagena CO, Panama Canal (Cruising), Puntarenas, Puerto Quetzal, Puerto Vallarta, San Diego, San Francisco, California
2026 Sails: Dec 18, More...
PONANT, Le Bellot
Le Bellot10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
Holland America, Zaandam
Zaandam15 Night - Panama Canal Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia36 Night - Caribbean to Cape Horn
Starting in Miami, Key West, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Panama Canal Daylight Transit, Manta, Salaverry, Lima / Machu Picchu (Callao), Pisco / Nazca Lines, Coquimbo, Santiago De Chile (San Antonio CL), Puerto Montt, Puerto Chacabuco, Laguna San Raphael, Cruising the Chilean Fjords, Punta Arenas, Cruising Around Cape Horn, Ushuaia, Port Stanley, Falkland Islands, Puerto Madryn, Punta Del Este, Buenos Aires
2026 Sails: Dec 19, More...

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Panama Cruises