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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Barro Colorado Island : Bocas del Toro : Cayos Limones : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Celebrity Cruises, Celebrity Ascent
Celebrity Ascent11 Night - Panama Canal & Southern Caribbean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal (Cruising), Colon, Panama, Oranjestad, Aruba, Willemstad AN, Curacao, Kralendijk, Bonaire, Fort Lauderdale, Florida
2026 Sails: Nov 23, 2027: Mar 8, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity19 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity28 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera, San Juan del Sur, Acajutla, Zihuatanejo, Manzanillo, Puerto Vallarta, San Diego
2026 Sails: Nov 23, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Caribbean with Costa Rica, Celebration Key & Panama Canal
Starting in Fort Lauderdale, Florida, Grand Cayman, Cayman Islands, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Nov 23, More...
Windstar, Wind Star
Wind Star11 Night - Colombian & Southern Caribbean Coastlines
Starting in Bridgetown, Bequia, St Georges, Kralendijk, Willemstad AN, Oranjestad, Cartagena CO, San Blas, Panama, Colon
2026 Sails: Nov 24, More...
Windstar, Wind Star
Wind Star18 Night - Star Collector : Reefs & Rainforests : the Caribbean, Colombia, Panama & Costa Rica via the Panama Canal
Starting in Bridgetown, Bequia, St Georges, Kralendijk, Willemstad AN, Oranjestad, Cartagena CO, San Blas, Panama, Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Nov 24, More...
Carnival Cruise Lines, Carnival Liberty
Carnival Liberty14 Night - Journeys - Caribbean & Panama
Starting in New Orleans, La, Montego Bay, Jamaica, Aruba, Curacao, Cartagena CO, Colon (Panama Canal), Panama, Limon, Costa Rica, Cozumel, Mexico, New Orleans, La
2026 Sails: Nov 29, 2027: Nov 28, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Dec 2, More...
Princess Cruises, Crown Princess
Crown Princess16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star16 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puntarenas / Puerto Caldera, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Dec 4, More...

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Panama Cruises