United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

Holland America, Zuiderdam

7 Night - Canada & New England Circle : New Brunswick
Starting in Boston, Massachusetts, Eastport, ME, Saint John NB, New Brunswick, Halifax, Nova Scotia, Canada, Sydney NS, Nova Scotia, Canada, Portland ME, Boston, Massachusetts
2026 Sails: Oct 3, More...

Lindblad Expeditions, National Geographic Venture

7 Night - Exploring British Columbia and the San Juan Islands
Starting in Seattle / Embark Ship, Victoria CA, Canada, Desolation Sound, Johnstone Strait / Alert Bay, Gulf Islands, Friday Harbor, San Juan Islands, Seattle / Disembark Ship
2026 Sails: Oct 3, Oct 10, Oct 17, More...

Margaritaville at Sea, Margaritaville Islander

7 Night - Jamaica & Western Caribbean
Starting in Port Tampa Bay, George Town, Grand Cayman, Ocho Rios, Jamaica, Cozumel, Mexico, Port Tampa Bay
2026 Sails: Oct 3, More...

MSC Cruises, MSC Poesia

14 Night - Msc Grand Voyages
Starting in San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 3, More...

Norwegian Cruise Line, Norwegian Bliss

7 Night - Alaska - Seattle
Starting in Seattle, Wa, Juneau, Ak, Skagway, Ak, Cruise Glacier Bay, Ak, Ketchikan (Ward Cove), Ak, Victoria CA, Canada, Seattle, Wa
2026 Sails: Oct 3, More...

Norwegian Cruise Line, Pride of America

7 Night - Hawaii Hnl Inter Island
Starting in Honolulu, Hi, Kahului, Maui, Hi, Hilo, Hi, Kona, Hi, Nawiliwili, Kauai, Hawaii, Cruise Napali Coast, Hi, Honolulu, Hi
2026 Sails: Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, Nov 7, Nov 14, Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, More...

Princess Cruises, Discovery Princess

7 Night - Mexican Riviera
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, Nov 7, Nov 14, Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Feb 6, Feb 13, Feb 20, Feb 27, Apr 17, Apr 24, More...

Princess Cruises, Majestic Princess

7 Night - Best of Canada & New England
Starting in New York City (Manhattan or Brooklyn), New York, Newport, Rhode Island, Boston, Massachusetts, Saint John NB (Bay of Fundy), Halifax, Canada, New York City (Manhattan or Brooklyn), New York
2026 Sails: Oct 3, More...

Princess Cruises, Regal Princess

7 Night - Western Caribbean with Mexico
Starting in Fort Lauderdale, Florida, Roatan (Isla Tropicale), Honduras, Belize City, Belize, Cozumel, Mexico, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...

Royal Caribbean, Enchantment of the Seas

7 Night - Western Caribbean Cruise
Starting in Tampa, Florida, Roatan, Honduras, Belize City, Belize, Puerto Costa Maya, Mexico, Cozumel, Mexico, Tampa, Florida
2026 Sails: Oct 3, Oct 17, More...

<= Back

More =>

United States Cruise Departures