United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

MSC Cruises, MSC World America

7 Night - Caribbean and Antilles
Starting in Miami, Florida, Isla De Roatan, Honduras, Costa Maya, Mexico, Cozumel, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Sep 12, Sep 26, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, 2027: Jan 2, Jan 16, Jan 30, Feb 13, Feb 27, Mar 13, Mar 27, More...

Norwegian Cruise Line, Norwegian Bliss

7 Night - Alaska - Seattle
Starting in Seattle, Wa, Sitka, Ak, Juneau, Ak, Icy Strait Point, Ak, Ketchikan (Ward Cove), Ak, Victoria CA, Canada, Seattle, Wa
2026 Sails: Sep 12, More...

Norwegian Cruise Line, Norwegian Escape

7 Night - Canada & New England - New York
Starting in New York City, Ny, Halifax, Canada, Saint John NB (Bay of Fundy), Boston, Ma, Portland ME, Newport, Ri, New York City, Ny
2026 Sails: Sep 12, More...

Princess Cruises, Regal Princess

7 Night - Eastern Caribbean with Puerto Rico
Starting in Fort Lauderdale, Florida, Amber Cove, Dominican Republic, San Juan, Puerto Rico, St Maarten, Fort Lauderdale, Florida
2026 Sails: Sep 12, Sep 26, More...

Princess Cruises, Royal Princess

7 Night - Inside Passage (with Glacier Bay National Park)
Starting in Seattle, Washington, Juneau, Alaska, Skagway, Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Ketchikan, Alaska, Victoria CA, Seattle, Washington
2026 Sails: Sep 12, More...

Royal Caribbean, Adventure of the Seas

6 Night - Western Caribbean Cruise
Starting in Orlando (Port Canaveral), Fl, Nassau, Bahamas, Puerto Plata, Dominican Republic, Grand Turk, Turks and Caicos, Orlando (Port Canaveral), Fl
2026 Sails: Sep 12, Oct 10, More...

Royal Caribbean, Enchantment of the Seas

7 Night - Western Caribbean Cruise
Starting in Tampa, Florida, Puerto Costa Maya, Mexico, Belize City, Belize, Roatan, Honduras, Cozumel, Mexico, Tampa, Florida
2026 Sails: Sep 12, Sep 26, Oct 10, 2027: Mar 7, More...

Royal Caribbean, Icon of the Seas

Deal link -> Special

7 Night - Eastern Caribbean & Perfect Day
Starting in Miami, Florida, Philipsburg, St Maarten, Charlotte Amalie, St Thomas, Perfect Day Cococay, Bahamas, Miami, Florida
2026 Sails: Sep 12, Sep 19, Oct 3, Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, 2027: Apr 24, May 8, May 15, Jun 5, Jun 19, Jun 26, Jul 10, Jul 17, Jul 31, More...

Royal Caribbean, Independence of the Seas

5 Night - Bermuda Getaway Cruise
Starting in Cape Liberty, Nj (Ny Metro), Royal Naval Dockyard, Bermuda, Cape Liberty, Nj (Ny Metro)
2026 Sails: Sep 12, Sep 26, Oct 10, Oct 24, 2027: May 27, Jun 5, Jun 19, Jun 24, Jul 3, Jul 17, Jul 22, Jul 31, Aug 14, Aug 19, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, More...

Royal Caribbean, Symphony of the Seas

8 Night - Western Caribbean & Perfect Day
Starting in Galveston, Texas, Perfect Day Cococay, Bahamas, Puerto Costa Maya, Mexico, Cozumel, Mexico, Galveston, Texas
2026 Sails: Sep 12, More...

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United States Cruise Departures