United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Departing from
United States
Cruise Specials

Carnival Cruise Lines, Carnival Spirit

7 Night - Bahamas
Starting in Mobile, Al, Key West, FL, Celebration Key, the Bahamas, Relaxaway, Half Moon Cay, Mobile, Al
2026 Sails: Oct 24, More...

Celebrity Cruises, Celebrity Reflection

9 Night - Aruba, Bonaire & Curacao Cruise
Starting in Fort Lauderdale, Florida, George Town, Grand Cayman, Oranjestad, Aruba, Willemstad AN, Curacao, Kralendijk, Bonaire, Fort Lauderdale, Florida
2026 Sails: Oct 24, More...

Disney Cruise Line, Disney Destiny

Deal link -> Special

5 Night - Western Caribbean Cruise from Fort Lauderdale
Starting in Port Everglades, Cozumel, Mexico, Castaway Cay, Port Everglades
2026 Sails: Oct 24, Nov 7, 2027: Jan 2, Jan 16, Feb 13, Mar 13, Mar 27, Apr 10, Apr 24, May 8, Jun 5, Jul 3, Jul 17, Aug 14, Sep 25, Oct 9, Oct 23, More...

Disney Cruise Line, Disney Magic

6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 24, More...

Disney Cruise Line, Disney Treasure

Deal link -> Special

7 Night - Eastern Caribbean Cruise from Port Canaveral
Starting in Port Canaveral, Tortola, St Thomas, US Virgin Islands, Castaway Cay, Port Canaveral
2026 Sails: Oct 24, 2027: Mar 27, Apr 10, Apr 24, May 8, May 22, More...

Holland America, Eurodam

7 Night - Eastern Caribbean : Amber Cove & Key West
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Key West, Florida, Fort Lauderdale, Florida
2026 Sails: Oct 24, More...

Lindblad Expeditions, National Geographic Sea Bird

7 Night - Columbia and Snake Rivers : Food, Wine and History
Starting in Clarkston, Washington / Embark Ship, Clarkston, Washington, Palouse River, Walla Walla, Cruising / The Dalles / Hood River, Astoria, Portland-OR, Oregon / Disembark Ship
2026 Sails: Oct 24, More...

Margaritaville at Sea, Margaritaville Islander

4 Night - Cozumel Express
Starting in Port Tampa Bay, Cozumel, Mexico, Port Tampa Bay
2026 Sails: Oct 24, Oct 28, Dec 10, Dec 19, 2027: Jan 21, Mar 9, Mar 23, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Jun 24, Jul 8, Jul 22, Jul 26, Sep 9, Sep 23, Nov 28, Dec 7, 2028: Apr 6, Apr 20, May 19, More...

MSC Cruises, MSC World America

7 Night - Caribbean and Antilles
Starting in Miami, Florida, Isla De Roatan, Honduras, Costa Maya, Mexico, Cozumel, Mexico, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida
2026 Sails: Oct 24, Nov 7, Nov 21, Dec 5, Dec 19, 2027: Jan 2, Jan 16, Jan 30, Feb 13, Feb 27, Mar 13, Mar 27, More...

Norwegian Cruise Line, Norwegian Sun

13 Night - Southern Caribbean - New York
Starting in New York City, Ny, Royal Naval Dockyard, Bermuda, San Juan, Pr, St Thomas, Vi, Tortola, British Virgin Islands, Willemstad AN, Netherlands Antilles, Oranjestad, Aruba, Cabo Rojo, Dominican Republic, Great Stirrup Cay, Bahamas, Miami, Fl
2026 Sails: Oct 24, More...

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United States Cruise Departures