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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maryland : Massachusetts : Minnesota : Missouri : New Jersey : New York State : Ohio : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin


American Countess Cruises5 Night - Lower Mississippi Cruise Roundtrip from New Orleans
Starting in New Orleans, LA; with stops in Nottoway Plantation; St. Francisville, LA; Baton Rouge, LA
2021 Sails: Jan 21, Jan 25, Jan 29, Feb 2, More...
Safari Explorer Cruises7 Night - Hawaiian Seascapes from Molokai to Hawai'i (Big Island)
Starting in Molokai; with stops in Olowalu; Honomalino Bay; Kailua; Kona; Hawai'i, the Big Island
2021 Sails: Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, Nov 27, Dec 11, Dec 25, 2022: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, More...
American Duchess Cruises8 Night - Lower Mississippi Cruise from Memphis to New Orleans
Starting in Memphis, TN; with stops in Helena, AR; Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Nottoway Plantation; New Orleans, LA
2021 Sails: Jan 24, Feb 7, May 16, Sep 5, Oct 24, Nov 7, Dec 19, More...
MSC Meraviglia Cruises14 Night - United States, Mexico, Cayman Islands, Jamaica, Bahamas, Puerto Rico, Virgin Islands (U.S.)
Starting in Miami with stops in Cozumel, George Town, Ocho Rios, Ocean Cay, San Juan, Charlotte Amalie, Nassau
2021 Sails: Jan 30, More...
Safari Explorer Cruises7 Night - Hawaiian Seascapes from Hawai'i (Big Island) to Molokai
Starting in Hawai'i (Big Island); with stops in Honomalino Bay; Kealakekua Bay; Lana'I; Olowalu; West Maui; Molokai
2021 Sails: Jan 30, Feb 13, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, Nov 20, Dec 4, Dec 18, 2022: Jan 1, Jan 15, Jan 29, Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, More...
American Duchess Cruises8 Night - Lower Mississippi Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway Plantation; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Jan 31, Feb 28, Mar 14, Mar 21, Mar 28, May 23, Aug 15, Sep 12, Oct 31, Nov 28, More...
Viking Sky Cruises14 Night - Panama Canal & Central America : Miami to Miami
Starting in Miami with stops in Key West, Scenic Cruising: Gulf of Mexico, Cozumel, Belize City, Roatan, Cruise the Caribbean Sea, Puerto Limon, Colon, Scenic Cruising: Panama Canal, Montego Bay
2021 Sails: Jan 31, More...
American Countess Cruises8 Night - Lower Mississippi Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway Plantation; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Greenville, TN; Memphis, TN
2021 Sails: Feb 6, Feb 20, Mar 6, Mar 20, Apr 17, May 1, May 15, May 29, Jun 26, Jul 10, Jul 24, Aug 7, Sep 11, Oct 23, More...
American Countess Cruises8 Night - Lower Mississippi Cruise from Memphis to New Orleans
Starting in Memphis, TN; with stops in Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Nottoway Plantation; New Orleans, LA
2021 Sails: Feb 13, Feb 27, Mar 13, Mar 27, Apr 24, May 8, May 22, Jun 19, Jul 3, Jul 17, Jul 31, Nov 13, More...
Viking Sky Cruises12 Night - Iconic Southern Caribbean : Miami to Miami
Starting in Miami with stops in Cruise the Atlantic Ocean, Cruise the Caribbean Sea, Oranjestad, Willemstad, Castries, St. Kitts, St. Thomas, San Juan
2021 Sails: Feb 14, Mar 9, More...


United States Cruise Departures

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