CruiseCompete: Easily Compare Multiple Offers from Cruise Experts
Compare offers from multiple travel agencies
1
Find your cruise
& request quotes
2
Compare members only prices,
upgrades, cabin credits & more!
3
Contact your preferred agent
for questions or to book your cruise
Over 1 million members
United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Georgia : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Michigan : Minnesota : Missouri : New Jersey : New York State : Ohio : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin


American Pride Cruises7 Night - Columbia and Snake Rivers Cruise from Clarkston, WA to Portland, OR
Starting in Clarkston, WA; with stops in Pendleton, OR; Richland, WA; The Dalles, OR; Cruising the Columbia River Gorge; Stevenson, WA; Mount St. Helens, WA; Astoria, OR; Portland, OR
2021 Sails: Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, Oct 15, Oct 29, Nov 12, Nov 26, 2022: Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 8, Jul 22, Aug 5, More...
American Star Cruises7 Night - Historic South and Golden Isles Cruise from Charleston, SC to Jacksonville, FL
Starting in Charleston, SC; with stops in Beaufort, SC; Hilton Head Island, SC; Savannah, GA; Cruising the Intercoastal Waterway; Jekyll Island, GA; St. Simons Island, GA; Amelia Island, FL; Jacksonville, FL
2021 Sails: Apr 24, 2022: Mar 26, Apr 9, Apr 23, 2023: Mar 25, Apr 8, Apr 22, More...
Independence Cruises14 Night - East Coast Inland Passage Cruise from Jacksonville, FL to Baltimore, MD
Starting in Jacksonville, FL / Amelia Island, FL; with stops in Fernandina Beach, FL; Jekyll Island, GA; St. Simons Island, GA; Savannah, GA; Hilton Head, SC; Beaufort, SC; Charleston, SC; Wilmington, NC; Beaufort, NC / Morehead City, NC; Kitty Hawk, NC; Norfolk, VA; St. Michaels, MD; Baltimore, MD
2021 Sails: Apr 24, 2022: Apr 23, 2023: Apr 22, More...
Independence Cruises7 Night - Historic South and Golden Isles Cruise from Jacksonville, FL to Charleston, SC
Starting in Jacksonville, FL; with stops in Amelia Island, FL; Jekyll Island, GA; St. Simons Island, GA; Cruising the Intercoastal Waterway; Savannah, GA; Hilton Head Island, SC; Beaufort, SC; Charleston, SC
2021 Sails: Apr 24, Nov 20, Dec 4, Dec 20, 2022: Feb 26, Mar 12, Mar 26, Apr 9, Nov 19, Dec 20, 2023: Feb 11, Feb 25, Mar 11, Mar 25, Apr 8, More...
Queen of the Mississippi Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Valley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis TN
2021 Sails: Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Nov 13, Nov 27, 2022: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 2, Oct 15, Oct 29, Nov 12, Nov 26, 2023: Feb 11, Feb 25, More...
American Countess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from Memphis to New Orleans
Starting in Memphis, TN; with stops in Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Nottoway; New Orleans, LA
2021 Sails: Apr 24, Jun 19, Jul 31, 2022: Nov 7, 2023: Mar 27, Apr 10, Apr 24, Sep 25, Oct 30, Nov 13, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: Apr 25, May 9, May 23, Jun 6, Jun 20, Sep 26, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 28, 2022: Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Sep 25, Oct 16, Oct 30, More...
American Song Cruises7 Night - Columbia and Snake Rivers Cruise from Clarkston, WA to Portland, OR
Starting in Clarkston, WA; with stops in Pendleton, OR; Richland, WA; The Dalles, OR; Cruising the Columbia River Gorge; Stevenson, WA; Mount St. Helens, WA; Astoria, OR; Portland, OR
2021 Sails: Apr 25, May 9, May 23, Jun 6, Jun 20, Jul 11, Jul 25, Aug 8, Aug 22, Sep 5, Oct 10, Oct 24, Nov 7, 2022: Mar 20, Apr 3, Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 10, Jul 24, Aug 7, Aug 21, More...
American Duchess Cruises8 Night - Special Edition Voyages - Special Events - The Kentucky Derby™ Cruise from Cincinnati to Louisville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Louisville, KY
2021 Sails: Apr 25, More...
American Duchess Cruises8 Night - Ohio River - The Beautiful Ohio Cruise from Cincinnati to Louisville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Louisville, KY
2021 Sails: Apr 25, More...


United States Cruise Departures

Connecting cruisers with the best cruise prices on discount cruises since 2003. Privacy Policy

Cruise news from Cruise Compete, where you compare cruise prices to get the best cruise discounts and deals
Let our Virtual Cruise Advisor(TM) recommend the best cruises for you.