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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Zuiderdam
Zuiderdam14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2027 Sails: Jan 16, More...
Zuiderdam7 Night - Mexican Riviera
Starting in San Diego, California, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2027 Sails: Jan 16, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 21, Feb 4, Feb 18, Mar 18, Mar 25, More...
Holland America, Zuiderdam
Zuiderdam7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2027 Sails: Jan 23, More...
Holland America, Koningsdam
Koningsdam18 Night - Circle Hawaii
Starting in San Diego, California, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kahului, Maui, Hilo, Hawaii, Kona, Hawaii, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 26, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Cabo, Mazatlan & La Paz
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, La Paz, Mexico, San Diego, California
2027 Sails: Jan 28, More...
Princess Cruises, Island Princess
Island Princess16 Night - Panama Canal - Ocean to Ocean
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2027 Sails: Jan 29, More...
Holland America, Zuiderdam
Zuiderdam15 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Miami, Florida
2027 Sails: Jan 30, More...
Norwegian Line Tours, Norwegian Star Tours
Norwegian Star Tours9 Night - San Diego City Highlights Cruisetour Package
Starting in At Hotel, San Diego, Ca, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, Ca
2027 Sails: Feb 4, More...
Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Puerto Vallarta, Cabo San Lucas, Ensenada, San Diego
2027 Sails: Feb 5, Mar 12, Apr 23, More...

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San Diego Cruise Departures