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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Norwegian Cruise Line, Norwegian Star
Norwegian Star16 Night - Repo - Panama Canal
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, George Town, Cayman Islands, Miami, Fl
2027 Sails: Feb 13, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & Mazatlan
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, Mazatlan, Mexico, San Diego, California
2027 Sails: Feb 28, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2027 Sails: Mar 7, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2027 Sails: Mar 8, Mar 22, More...
Holland America, Koningsdam
Koningsdam18 Night - Baja Peninsula, Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Mar 20, More...
Holland America, Koningsdam
Koningsdam14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Mar 20, More...
Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Mar 26, More...
Holland America, Koningsdam
Koningsdam11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Mar 27, 2028: Apr 1, More...
Holland America, Koningsdam
Koningsdam7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Mar 27, 2028: Apr 1, More...
Holland America, Koningsdam
Koningsdam28 Night - Mexico Riviera, Pacific Coastal & Circle Hawaii
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kona, Hawaii, Kahului, Maui, Hilo, Hawaii, Vancouver, BC, CA
2027 Sails: Mar 27, More...

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San Diego Cruise Departures