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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Crystal, Crystal Serenity
Crystal Serenity Cruise Ship18 Night - The Americas & Caribbean
Starting in San Diego, California, Topolobampo, Loreto, La Paz, Isla Natividad (Sightseeing Only), San Diego, California, Manzanillo, Puerto Vallarta, Mazatlan, Cabo San Lucas (Baja California Sur), San Diego, California
2026 Sails: Dec 21, More...
Crystal, Crystal Serenity
Crystal Serenity Cruise Ship9 Night - The Americas & Caribbean
Starting in San Diego, California, Topolobampo, Loreto, La Paz, Isla Natividad (Sightseeing Only), San Diego, California
2026 Sails: Dec 21, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship7 Night - Very Merrytime Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, Puerto Vallarta, San Diego
2026 Sails: Dec 22, More...
Holland America Line, Koningsdam
Koningsdam Cruises14 Night - Mexican Riviera & Baja Peninsula Holiday
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Dec 26, More...
Holland America Line, Koningsdam
Koningsdam Cruises7 Night - Mexican Riviera Holiday
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 26, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star Cruise Ship7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, Ca
2026 Sails: Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Mar 27, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Cabo, Mazatlan & La Paz Holiday
Starting in San Diego, California, Mazatlan, Mexico, La Paz, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 27, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship5 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Dec 29, More...
Crystal, Crystal Serenity
Crystal Serenity Cruise Ship9 Night - The Americas & Caribbean
Starting in San Diego, California, Manzanillo, Puerto Vallarta, Mazatlan, Cabo San Lucas (Baja California Sur), San Diego, California
2026 Sails: Dec 30, More...
Holland America Line, Koningsdam
Koningsdam Cruises24 Night - Mexico Riviera & Circle Hawaii
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Honolulu, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Hilo, Hawaii, Kona, Hawaii, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 2, More...

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San Diego Cruise Departures