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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship7 Night - Very Merrytime Mexican Riviera Cruise from San Diego
Starting in San Diego, Mazatlan, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Nov 22, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Cabo, Mazatlan & La Paz Cruise
Starting in San Diego, California, Cabo San Lucas, Mexico, La Paz, Mexico, Mazatlan, Mexico, San Diego, California
2026 Sails: Nov 22, Dec 20, More...
Holland America Line, Koningsdam
Koningsdam Cruises10 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Nov 28, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 3, Dec 10, More...
Holland America Line, Zaandam
Zaandam Cruise Ship12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 7, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Cabo Overnight, Catalina & Ensenada
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 13, More...
Holland America Line, Koningsdam
Koningsdam Cruises7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Dec 19, 2027: Jan 2, Mar 20, More...
Holland America Line, Koningsdam
Koningsdam Cruises14 Night - Mexican Riviera & Baja Peninsula Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 19, More...
Holland America Line, Zaandam
Zaandam Cruise Ship15 Night - Panama Canal Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star Cruise Ship6 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Dec 20, More...

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San Diego Cruise Departures