San Diego Cruises
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
39 Night - The Americas & Caribbean
Starting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...
7 Night - Classic California Coast
Starting in San Francisco, California, Catalina Island, California, Los Angeles, California, San Diego, California, Ensenada, Mexico, San Francisco, California
2026 Sails: Sep 10, More...
8 Night - Pacific Coastal : Vancouver to La
Starting in Vancouver, British Columbia, Canada, San Francisco, California, Santa Barbara, California, Catalina Island, California, San Diego, California, Los Angeles, California
2026 Sails: Sep 11, More...
26 Night - Msc Grand Voyages
Starting in Seattle, Washington, Ketchikan, Alaska, Sitka, Alaska, Endicott Arm and Dawes Glacier, Juneau, Alaska, Victoria CA, Canada, Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 21, More...
22 Night - Panama Canal & Pacific Coast
Starting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 23, More...6 Night - Pacific Wine Country
Starting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California
2026 Sails: Sep 23, More...
7 Night - Pacific Wine Country
Starting in Vancouver, Canada, San Francisco, California, San Diego, California, Santa Barbara, California, Los Angeles, California
2026 Sails: Sep 26, More...
21 Night - Panama Canal
Starting in Vancouver, BC, CA, San Francisco, California, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Sep 27, More...19 Night - MSC Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...24 Night - MSC Grand Voyages
Starting in Seattle, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Panama Canal (Transit), Panama, Colon, Panama, Cartagena CO, Colombia, Miami, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami
2026 Sails: Sep 28, More...
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
Click on a cruise ship itinerary that visits San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
39 Night - The Americas & CaribbeanStarting in Vancouver, Victoria CA, Canada, Astoria, Eureka, California, San Francisco, San Diego, Ensenada, Cabo San Lucas (Baja California Sur), Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Santo Domingo, Punta Cana, San Juan, Marigot, St Martin, Roseau, Bridgetown, Castries, St Lucia, St Johns, Jost Van Dyke, British Virgin Islands, Samana, Grand Turk, New York
2026 Sails: Aug 17, More...
7 Night - Classic California CoastStarting in San Francisco, California, Catalina Island, California, Los Angeles, California, San Diego, California, Ensenada, Mexico, San Francisco, California
2026 Sails: Sep 10, More...
8 Night - Pacific Coastal : Vancouver to LaStarting in Vancouver, British Columbia, Canada, San Francisco, California, Santa Barbara, California, Catalina Island, California, San Diego, California, Los Angeles, California
2026 Sails: Sep 11, More...
26 Night - Msc Grand VoyagesStarting in Seattle, Washington, Ketchikan, Alaska, Sitka, Alaska, Endicott Arm and Dawes Glacier, Juneau, Alaska, Victoria CA, Canada, Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 21, More...
22 Night - Panama Canal & Pacific CoastStarting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 23, More...
6 Night - Pacific Wine CountryStarting in Vancouver, Canada, San Francisco, California, San Diego, California, Los Angeles, California
2026 Sails: Sep 23, More...
7 Night - Pacific Wine CountryStarting in Vancouver, Canada, San Francisco, California, San Diego, California, Santa Barbara, California, Los Angeles, California
2026 Sails: Sep 26, More...
21 Night - Panama CanalStarting in Vancouver, BC, CA, San Francisco, California, San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Sep 27, More...
19 Night - MSC Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...
24 Night - MSC Grand VoyagesStarting in Seattle, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Panama Canal (Transit), Panama, Colon, Panama, Cartagena CO, Colombia, Miami, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami
2026 Sails: Sep 28, More...
