San Diego Cruises
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
20 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA, Seattle, Washington
2026 Sails: Apr 5, More...19 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 5, More...
32 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 9, More...
22 Night - Panama Canal
Starting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
20 Night - Miami to Seattle
Starting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA
2026 Sails: Apr 14, More...30 Night - Miami to Seattle
Starting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 14, More...
33 Night - Grand World Voyage
Starting in Yokohama (Tokyo), Japan, Hakodate, Japan, Cross International Dateline, Kodiak, Alaska, Sitka, Alaska, Ketchikan, Alaska, Seattle, Washington, San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Apr 14, More...
14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
7 Night - Classic California Coast
Starting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...18 Night - Msc Grand Voyages
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
Cruises that visit North America: United States: California: San Diego
Cruises that depart from San Diego
Click on a cruise ship itinerary that visits San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.
20 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA, Seattle, Washington
2026 Sails: Apr 5, More...
19 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 5, More...
32 Night - Msc Grand VoyagesStarting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Philipsburg, St Maarten, Ocean Cay Msc Marine Reserve, Bahamas, Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 9, More...
22 Night - Panama CanalStarting in Fort Lauderdale, Florida, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Puntarenas (Puerto Caldera), Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Puerto Chiapas, Mexico, Manzanillo, Mexico, Puerto Vallarta, Mexico, San Diego, California, San Francisco, California, Vancouver, BC, CA
2026 Sails: Apr 10, More...
20 Night - Miami to SeattleStarting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA
2026 Sails: Apr 14, More...
Deal link -> Special
30 Night - Miami to SeattleStarting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 14, More...
33 Night - Grand World VoyageStarting in Yokohama (Tokyo), Japan, Hakodate, Japan, Cross International Dateline, Kodiak, Alaska, Sitka, Alaska, Ketchikan, Alaska, Seattle, Washington, San Diego, California, Manzanillo, Mexico, Puerto Chiapas, Mexico, Acajutla, El Salvador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Apr 14, More...
14 Night - Mexican Riviera & Baja PeninsulaStarting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
7 Night - Classic California CoastStarting in San Francisco, California, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California, San Francisco, California
2026 Sails: Apr 19, More...
18 Night - Msc Grand VoyagesStarting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
