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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, Mazatlan, San Diego
2027 Sails: Sep 24, More...
Disney Magic5 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Sep 25, More...
Disney Magic3 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2027 Sails: Sep 30, Oct 21, More...
Disney Magic7 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, Puerto Vallarta, San Diego
2027 Sails: Oct 3, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Oct 4, Oct 18, Nov 8, Nov 15, 2028: Jan 10, Jan 24, Feb 21, Mar 16, Mar 20, Mar 27, Apr 3, Apr 13, Apr 17, Apr 24, More...
Holland America, Eurodam
Eurodam16 Night - Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2027 Sails: Oct 7, More...
Holland America, Zaandam
Zaandam7 Night - Mexican Riviera
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2027 Sails: Oct 7, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas15 Night - Panama Canal Eastward Cruise
Starting in San Diego, California, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama Canal (Cruising), Cartagena CO, George Town, Grand Cayman, Tampa, Florida
2027 Sails: Oct 7, More...
Disney Magic6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2027 Sails: Oct 10, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Oct 11, More...

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San Diego Cruise Departures