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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Royal Caribbean, Serenade of the Seas
Serenade of the Seas4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2027 Sails: Feb 7, Mar 21, More...
Norwegian Line Tours, Norwegian Star Tours
Norwegian Star Tours18 Night - San Diego City Highlights Cruisetour Package
Starting in At Hotel, San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, George Town, Cayman Islands, Miami, Fl
2027 Sails: Feb 11, More...
Holland America, Koningsdam
Koningsdam35 Night - Legendary Hawaii, Tahiti & Marquesas
Starting in San Diego, California, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2027 Sails: Feb 13, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star16 Night - Repo - Panama Canal
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, George Town, Cayman Islands, Miami, Fl
2027 Sails: Feb 13, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & Mazatlan
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, Mazatlan, Mexico, San Diego, California
2027 Sails: Feb 28, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2027 Sails: Mar 7, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2027 Sails: Mar 8, Mar 22, More...
Holland America, Koningsdam
Koningsdam18 Night - Baja Peninsula, Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Mar 20, More...
Holland America, Koningsdam
Koningsdam14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Mar 20, More...
Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Mar 26, More...

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San Diego Cruise Departures