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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Very Merrytime Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, Puerto Vallarta, San Diego
2026 Sails: Dec 22, More...
Holland America, Koningsdam
Koningsdam14 Night - Mexican Riviera & Baja Peninsula Holiday
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Dec 26, More...
Holland America, Koningsdam
Koningsdam7 Night - Mexican Riviera Holiday
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 26, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, Ca
2026 Sails: Dec 26, 2027: Feb 6, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Cabo, Mazatlan & La Paz Holiday
Starting in San Diego, California, Mazatlan, Mexico, La Paz, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 27, More...
Disney Cruise Line, Disney Wonder
Disney Wonder5 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Dec 29, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity9 Night - The Americas & Caribbean
Starting in San Diego, Manzanillo, Puerto Vallarta, Mazatlan, Cabo San Lucas (Baja California Sur), San Diego
2026 Sails: Dec 30, More...
Norwegian Line Tours, Norwegian Star Tours
Norwegian Star Tours9 Night - San Diego City Highlights Cruisetour Package
Starting in At Hotel, San Diego, Ca, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, San Diego, Ca
2026 Sails: Dec 31, 2027: Jan 28, More...
Holland America, Koningsdam
Koningsdam24 Night - Mexico Riviera & Circle Hawaii
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Honolulu, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Hilo, Hawaii, Kona, Hawaii, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 2, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, San Diego, Ca
2027 Sails: Jan 2, Jan 30, More...

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San Diego Cruise Departures