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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Koningsdam
Koningsdam10 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Nov 28, 2027: Nov 27, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 3, Dec 10, More...
Holland America, Zaandam
Zaandam12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 7, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Cabo Overnight, Catalina & Ensenada
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 13, More...
Koningsdam7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Dec 19, 2027: Jan 2, Mar 20, More...
Holland America, Koningsdam
Koningsdam14 Night - Mexican Riviera & Baja Peninsula Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Dec 19, More...
Holland America, Zaandam
Zaandam15 Night - Panama Canal Holiday
Starting in San Diego, California, Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Fort Lauderdale, Florida
2026 Sails: Dec 19, More...
Norwegian Cruise Line, Norwegian Star
Norwegian Star6 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Dec 20, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity18 Night - The Americas & Caribbean
Starting in San Diego, Topolobampo, Loreto, La Paz, Isla Natividad (Sightseeing Only), San Diego, Manzanillo, Puerto Vallarta, Mazatlan, Cabo San Lucas (Baja California Sur), San Diego
2026 Sails: Dec 21, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity9 Night - The Americas & Caribbean
Starting in San Diego, Topolobampo, Loreto, La Paz, Isla Natividad (Sightseeing Only), San Diego
2026 Sails: Dec 21, More...

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San Diego Cruise Departures