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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 11, Nov 29, Dec 6, More...
Holland America Line, Zaandam
Zaandam Cruise Ship35 Night - Legendary Hawaii, Tahiti & Marquesas
Starting in San Diego, California, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kahului, Maui, Kona, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Avatoru, Rangiroa, French Polynesia, Huahine, French Polynesia, Bora Bora, French Polynesia, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2026 Sails: Oct 15, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 15, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Oct 18, Nov 9, 2027: Jan 3, Jan 25, Feb 22, Mar 29, Apr 19, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Ensenada, Cabo & La Paz Cruise
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, La Paz, Mexico, San Diego, California
2026 Sails: Oct 18, Nov 15, More...
Disney Cruise Line, Disney Magic
Disney Magic Cruise Ship5 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 19, More...
Holland America Line, Koningsdam
Koningsdam Cruises11 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Manzanillo, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Oct 20, Dec 8, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship5 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 22, Nov 29, 2027: Jan 10, Apr 2, More...
Disney Cruise Line, Disney Magic
Disney Magic Cruise Ship6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 24, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, San Diego
2026 Sails: Oct 27, More...

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San Diego Cruise Departures