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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Koningsdam7 Night - Classic California Coast
Starting in San Diego, California, Avalon, California, San Francisco, California, Ensenada, Mexico, San Diego, California
2026 Sails: Nov 14, More...
Disney Cruise Line, Disney Wonder
Disney Wonder6 Night - Very Merrytime Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, San Diego
2026 Sails: Nov 16, More...
Holland America, Zaandam
Zaandam30 Night - Circle Hawaii & Sea of Cortez
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Ensenada, Mexico, San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Nov 19, More...
Zaandam18 Night - Circle Hawaii Holiday
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Ensenada, Mexico, San Diego, California
2026 Sails: Nov 19, More...
Koningsdam7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Nov 21, 2027: Nov 6, More...
Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Very Merrytime Mexican Riviera Cruise from San Diego
Starting in San Diego, Mazatlan, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Nov 22, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Cabo, Mazatlan & La Paz Cruise
Starting in San Diego, California, Cabo San Lucas, Mexico, La Paz, Mexico, Mazatlan, Mexico, San Diego, California
2026 Sails: Nov 22, Dec 20, More...
Koningsdam10 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Nov 28, 2027: Nov 27, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 3, Dec 10, More...
Zaandam12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Dec 7, More...

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San Diego Cruise Departures