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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Royal Caribbean, Serenade of the Seas
Serenade of the Seas3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 15, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Oct 18, Nov 9, 2027: Jan 3, Jan 25, Feb 22, Mar 29, Apr 19, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & La Paz Cruise
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, La Paz, Mexico, San Diego, California
2026 Sails: Oct 18, Nov 15, More...
Disney Cruise Line, Disney Magic
Disney Magic5 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 19, More...
Koningsdam11 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Manzanillo, Mexico, Puerto Vallarta, Mexico, Mazatlan, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Cabo San Lucas, Mexico, San Diego, California
2026 Sails: Oct 20, Dec 8, More...
Disney Cruise Line, Disney Wonder
Disney Wonder5 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 22, Nov 29, 2027: Jan 10, Apr 2, More...
Disney Cruise Line, Disney Magic
Disney Magic6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 24, More...
Disney Cruise Line, Disney Wonder
Disney Wonder6 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Ensenada, Cabo San Lucas, San Diego
2026 Sails: Oct 27, More...
Disney Cruise Line, Disney Magic
Disney Magic7 Night - Halloween On the High Seas Mexican Riviera Cruise from San Diego
Starting in San Diego, Puerto Vallarta, Cabo San Lucas, Ensenada, San Diego
2026 Sails: Oct 30, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & Mazatlan Cruise
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, Mazatlan, Mexico, San Diego, California
2026 Sails: Nov 1, Nov 8, More...

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San Diego Cruise Departures