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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America Line, Nieuw Amsterdam
Nieuw Amsterdam Cruise Ship25 Night - Pacific Coastal & Circle Hawaii Collector
Starting in San Diego, California, Avalon, California, San Francisco, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Hilo, Hawaii, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 4, More...
Norwegian Cruise Line, Norwegian Jade
Norwegian Jade Cruise Ship7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Apr 4, More...
Holland America Line, Zaandam
Zaandam Cruise Ship11 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Cruising Bahia Magdalena, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, San Diego, California
2026 Sails: Apr 7, More...
Norwegian Cruise Line, Norwegian Jade
Norwegian Jade Cruise Ship8 Night - Repo - Pacific Coastal
Starting in San Diego, Ca, San Francisco, Ca, Astoria, Or, Seattle, Wa, Victoria CA, Canada, Vancouver, Canada
2026 Sails: Apr 11, More...
Holland America Line, Zaandam
Zaandam Cruise Ship7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Apr 18, More...
Holland America Line, Zaandam
Zaandam Cruise Ship18 Night - Baja Peninsula, Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 18, More...
Holland America Line, Zaandam
Zaandam Cruise Ship14 Night - Mexican Riviera & Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2026 Sails: Apr 18, More...
Disney Magic Cruise Ship4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Apr 19, More...
Holland America Line, Eurodam
Eurodam Cruise Ship4 Night - Pacific Coastal Cruise
Starting in San Diego, California, Avalon, California, Vancouver, BC, CA
2026 Sails: Apr 20, More...
Disney Cruise Line, Disney Magic
Disney Magic Cruise Ship4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Apr 23, More...

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San Diego Cruise Departures