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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & La Paz Cruise
Starting in San Diego, California, La Paz, Mexico, Cabo San Lucas, Mexico, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 4, Oct 25, More...
Disney Cruise Line, Disney Magic
Disney Magic4 Night - Halloween On the High Seas Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Oct 5, More...
Holland America, Eurodam
Eurodam16 Night - Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 8, More...
Holland America, Zaandam
Zaandam7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Oct 8, More...
Disney Cruise Line, Disney Wonder
Disney Wonder3 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Oct 10, Dec 15, 2027: Feb 12, Feb 26, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 11, Nov 29, Dec 6, More...
Holland America, Zaandam
Zaandam35 Night - Legendary Hawaii, Tahiti & Marquesas
Starting in San Diego, California, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kahului, Maui, Kona, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Avatoru, Rangiroa, French Polynesia, Huahine, French Polynesia, Bora Bora, French Polynesia, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2026 Sails: Oct 15, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2026 Sails: Oct 15, More...
Disney Cruise Line, Disney Wonder
Disney Wonder4 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Oct 18, Nov 9, 2027: Jan 3, Jan 25, Feb 22, Mar 29, Apr 19, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Ensenada, Cabo & La Paz Cruise
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, La Paz, Mexico, San Diego, California
2026 Sails: Oct 18, Nov 15, More...

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San Diego Cruise Departures