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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America Line (HAL), HAL Zuiderdam
HAL Zuiderdam Cruise Ship15 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, Half Moon Cay, Bahamas, Miami, Florida
2026 Sails: Feb 27, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 2, Mar 23, Mar 30, Apr 13, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship3 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 6, Mar 13, Mar 20, Apr 3, Apr 10, Apr 17, May 1, More...
Oceania Cruises, Oceania Vista
Oceania Vista Cruises16 Night - Pacific Lagoons & Retreats
Starting in San Diego, Honolulu, Kailua-Kona, Nuku Hiva, Rangiroa, Moorea, Papeete (Tahiti)
2026 Sails: Mar 7, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship4 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2026 Sails: Mar 9, Mar 16, Apr 6, Apr 20, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship3 Night - Baja Cruise from San Diego
Starting in San Diego, Ensenada, San Diego
2026 Sails: Mar 27, May 4, More...
Holland America Line (HAL), HAL Nieuw Amsterdam
HAL Nieuw Amsterdam Cruise Ship14 Night - Baja Peninsula, Wine Country and Pnw
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California, Avalon, California, San Francisco, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Mar 28, More...
Holland America Line (HAL), HAL Nieuw Amsterdam
HAL Nieuw Amsterdam Cruise Ship7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2026 Sails: Mar 28, More...
Norwegian Cruise Line (NCL), NCL Norwegian Jade
NCL Norwegian Jade Cruise Ship7 Night - Mexican Riviera - San Diego
Starting in San Diego, Ca, Mazatlan, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Mar 28, More...
Holland America Line (HAL), HAL Nieuw Amsterdam
HAL Nieuw Amsterdam Cruise Ship7 Night - Wine Country & Pacific Northwest
Starting in San Diego, California, Avalon, California, San Francisco, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2026 Sails: Apr 4, More...

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San Diego Cruise Departures