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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Koningsdam
Koningsdam7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, San Diego, California
2027 Sails: Nov 6, More...
Holland America, Koningsdam
Koningsdam14 Night - Classic California Coast & Mexican Riviera
Starting in San Diego, California, Ensenada, Mexico, San Francisco, California, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Nov 13, More...
Holland America, Koningsdam
Koningsdam7 Night - Classic California Coast
Starting in San Diego, California, Ensenada, Mexico, San Francisco, California, Santa Barbara, California, San Diego, California
2027 Sails: Nov 13, More...
Holland America, Zaandam
Zaandam18 Night - Circle Hawaii
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California
2027 Sails: Nov 18, More...
Holland America, Zaandam
Zaandam30 Night - Circle Hawaii & Sea of Cortez
Starting in San Diego, California, Hilo, Hawaii, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Ensenada, Mexico, San Diego, California, Cabo San Lucas, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2027 Sails: Nov 18, More...
Holland America, Koningsdam
Koningsdam7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Nov 20, 2028: Jan 8, More...
Disney Cruise Line, Disney Wonder
Disney Wonder5 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Dec 5, 2028: Jan 2, More...
Holland America, Zaandam
Zaandam12 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Ensenada, Mexico, San Diego, California
2027 Sails: Dec 6, More...
Holland America, Koningsdam
Koningsdam11 Night - Mexican Riviera & Sea of Cortez
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, Mazatlan, Mexico, San Diego, California
2027 Sails: Dec 7, More...
Disney Cruise Line, Disney Wonder
Disney Wonder5 Night - Very Merrytime Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Dec 10, More...

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San Diego Cruise Departures