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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Nieuw Amsterdam
Nieuw Amsterdam4 Night - Pacific Coastal Cruise
Starting in San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Apr 28, More...
Disney Cruise Line, Disney Wonder
Disney Wonder6 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2027 Sails: Apr 30, More...
Royal Caribbean, Serenade of the Seas
Serenade of the Seas7 Night - Pacific Coastal Cruise
Starting in San Diego, California, Astoria, Oregon, Seattle, Washington, Victoria CA, Canada, Vancouver, British Columbia
2027 Sails: May 2, More...
Azamara Cruises, Azamara Quest
Azamara Quest17 Night - Panama Canal & Latin America Cruise : Mexico, Costa Rica & Colombia
Starting in San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas, Panama Canal (Cruising), Cartagena CO, Miami, Florida
2027 Sails: May 24, More...
Azamara Cruises, Azamara Quest
Azamara Quest35 Night - San Diego to London Grand Voyage
Starting in San Diego, Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas, Panama Canal (Cruising), Cartagena CO, Miami, Florida, New York City, New York, Newport, Rhode Island, Cape Cod Canal Cruising, Boston, Massachusetts, Halifax, Nova Scotia, St Johns NF, Newfoundland, Cobh, Plymouth, England, Le Havre, London (Tilbury), England
2027 Sails: May 24, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity25 Night - The Americas & Caribbean
Starting in San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 9, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity11 Night - The Americas & Caribbean
Starting in San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City)
2027 Sails: Aug 9, More...
Holland America, Eurodam
Eurodam16 Night - Panama Canal
Starting in San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2027 Sails: Oct 7, More...

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San Diego Cruise Departures