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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Holland America, Koningsdam
Koningsdam11 Night - Mexican Riviera & Pacific Coast
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Mar 27, 2028: Apr 1, More...
Holland America, Koningsdam
Koningsdam7 Night - Mexican Riviera
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California
2027 Sails: Mar 27, 2028: Apr 1, More...
Holland America, Koningsdam
Koningsdam28 Night - Mexico Riviera, Pacific Coastal & Circle Hawaii
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, San Diego, California, Victoria CA, Canada, Vancouver, BC, CA, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kona, Hawaii, Kahului, Maui, Hilo, Hawaii, Vancouver, BC, CA
2027 Sails: Mar 27, More...
Holland America, Zaandam
Zaandam7 Night - Mexican Riviera
Starting in San Diego, California, Puerto Vallarta, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, California
2027 Sails: Mar 28, More...
Holland America, Koningsdam
Koningsdam4 Night - Pacific Coastal Cruise
Starting in San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Apr 3, 2028: Apr 8, More...
Holland America, Zaandam
Zaandam13 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, Ensenada, Mexico, San Diego, California
2027 Sails: Apr 4, More...
Disney Cruise Line, Disney Wonder
Disney Wonder7 Night - Dvc Charter
Starting in San Diego, Catalina, San Francisco, Ensenada, San Diego
2027 Sails: Apr 7, More...
Disney Cruise Line, Disney Wonder
Disney Wonder5 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Apr 14, More...
Holland America, Eurodam
Eurodam6 Night - Pacific Coastal Cruise
Starting in San Diego, California, San Francisco, California, Vancouver, BC, CA
2027 Sails: Apr 17, More...
Holland America, Zaandam
Zaandam7 Night - Wine Country & Pacific Northwest
Starting in San Diego, California, Avalon, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Apr 17, More...

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San Diego Cruise Departures