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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship3 Night - Ensenada Cruise
Starting in San Diego, California, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 21, Feb 4, Feb 18, Mar 18, Mar 25, More...
Holland America Line, Zuiderdam
Zuiderdam Cruise Ship7 Night - Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Pichilingue (La Paz), Mexico, Loreto, Mexico, San Diego, California
2027 Sails: Jan 23, More...
Holland America Line, Koningsdam
Koningsdam Cruises18 Night - Circle Hawaii
Starting in San Diego, California, Nawiliwili, Kauai, Hawaii, Honolulu, Hawaii, Kahului, Maui, Hilo, Hawaii, Kona, Hawaii, Ensenada, Mexico, San Diego, California
2027 Sails: Jan 26, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Cabo, Mazatlan & La Paz
Starting in San Diego, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, La Paz, Mexico, San Diego, California
2027 Sails: Jan 28, More...
Princess Cruises, Island Princess
Island Princess Cruise Ship16 Night - Panama Canal - Ocean to Ocean
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2027 Sails: Jan 29, More...
Holland America Line, Zuiderdam
Zuiderdam Cruise Ship15 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Miami, Florida
2027 Sails: Jan 30, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship7 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Puerto Vallarta, Cabo San Lucas, Ensenada, San Diego
2027 Sails: Feb 5, Mar 12, Apr 23, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship4 Night - Catalina & Ensenada Cruise
Starting in San Diego, California, Catalina Island, California, Ensenada, Mexico, San Diego, California
2027 Sails: Feb 7, Mar 21, More...
Holland America Line, Koningsdam
Koningsdam Cruises35 Night - Legendary Hawaii, Tahiti & Marquesas
Starting in San Diego, California, Kona, Hawaii, Kahului, Maui, Honolulu, Hawaii, Nawiliwili, Kauai, Hawaii, Cross International Dateline, Tabuaeran (Fanning Island), Kiribati, Crossing the Equator, Cross International Dateline, Raiatea, Society Islands, French Polynesia, Papeete, French Polynesia, Bahia d Opunoha, Moorea, French Polynesia, Fakarava, Tuamotu, French Polynesia, Taiohae, Nuku Hiva, French Polynesia, Crossing the Equator, San Diego, California
2027 Sails: Feb 13, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Ensenada, Cabo & Mazatlan
Starting in San Diego, California, Ensenada, Mexico, Cabo San Lucas, Mexico, Mazatlan, Mexico, San Diego, California
2027 Sails: Feb 28, More...

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San Diego Cruise Departures