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San Diego Cruise Departures

Cruises that depart from North America: United States: California: San Diego

Cruises that visit San Diego

Click on a cruise ship itinerary sailing from San Diego (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just San Diego), please visit: Cruise Search or try our Virtual Cruise Advisor™.



Norwegian Cruise Line, Norwegian Star
Norwegian Star Cruise Ship15 Night - Repo - Panama Canal
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2027 Sails: Apr 3, More...
Holland America Line, Zaandam
Zaandam Cruise Ship13 Night - Historical Baja Peninsula
Starting in San Diego, California, Cabo San Lucas, Mexico, Loreto, Mexico, Guaymas, Mexico, Topolobampo, Mexico, Pichilingue (La Paz), Mexico, Mazatlan, Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, Ensenada, Mexico, San Diego, California
2027 Sails: Apr 4, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship5 Night - Baja Cruise from San Diego
Starting in San Diego, Catalina, Ensenada, San Diego
2027 Sails: Apr 14, More...
Holland America Line, Eurodam
Eurodam Cruise Ship6 Night - Pacific Coastal Cruise
Starting in San Diego, California, San Francisco, California, Vancouver, BC, CA
2027 Sails: Apr 17, More...
Holland America Line, Zaandam
Zaandam Cruise Ship7 Night - Wine Country & Pacific Northwest
Starting in San Diego, California, Avalon, California, Santa Barbara, California, Astoria, Oregon, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Apr 17, More...
Holland America Line, Nieuw Amsterdam
Nieuw Amsterdam Cruise Ship4 Night - Pacific Coastal Cruise
Starting in San Diego, California, Victoria CA, Canada, Vancouver, BC, CA
2027 Sails: Apr 28, More...
Disney Cruise Line, Disney Wonder
Disney Wonder Cruise Ship6 Night - Mexican Riviera Cruise from San Diego
Starting in San Diego, Cabo San Lucas, Ensenada, San Diego
2027 Sails: Apr 30, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Pacific Coastal Cruise
Starting in San Diego, California, Astoria, Oregon, Seattle, Washington, Victoria CA, Canada, Vancouver, British Columbia
2027 Sails: May 2, More...

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San Diego Cruise Departures