Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Norwegian Cruise Line, Norwegian Epic

7 Night - Europe
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Livorno / Florence / Pisa, Italy, Nice / Monaco (Villefranche), France, Provence, Marseille, France, Barcelona, Spain
2026 Sails: May 24, Jun 7, Jun 21, Jul 5, Jul 19, Aug 2, Aug 16, Aug 30, Sep 13, More...

Norwegian Cruise Line, Norwegian Gem

7 Night - Europe - Adriatic & Greece - Venice
Starting in Venice (Ravenna), Italy, Koper, Slovenia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 24, More...

Regent Seven Seas, Seven Seas Grandeur

13 Night - Spotlight On Faberge
Starting in Rome (Civitavecchia), Tuscany (Livorno), Monte Carlo, Barcelona, Cruising the Mediterranean Sea, Cruising the Atlantic Ocean, La Coruna, Cruising the English Channel, Paris (Honfleur), London (Southampton)
2026 Sails: May 24, More...

Royal Caribbean, Odyssey of the Seas

7 Night - Greek Isles Cruise
Starting in Rome (Civitavecchia), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, More...

Uniworld, S.S. La Venezia

7 Night - Venice & the Jewels of Veneto
Starting in Venice, Venice (Padua), Mazzorbo (Burano), Mazzorbo, Burano, Chioggia, Chioggia, Chioggia, Venice, Venice
2026 Sails: May 24, May 31, Jun 7, Jun 14, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, Nov 1, 2027: Apr 18, More...

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Istanbul, Turkey, Ephesus (Kusadasi), Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 25, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 25, Jun 8, Jun 15, Jun 22, Jun 29, Jul 13, Jul 20, Jul 27, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy
2026 Sails: May 25, Jun 1, Jun 8, Jun 15, Jun 22, Jun 29, Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, Oct 19, Oct 26, Nov 2, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 25, Jul 6, Sep 28, More...

Virgin Voyages, Valiant Lady

6 Night - Mediterranean : Rome to Barcelona
Starting in Civitavecchia (Rome), Italy, Amalfi Coast (Salerno), Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: May 25, More...

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