Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Princess Cruises, Sapphire Princess

14 Night - Mediterranean with Greece, Italy & Croatia
Starting in Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 8, Mar 22, Apr 5, More...

Princess Cruises, Sapphire Princess

7 Night - Mediterranean with Greece & Italy
Starting in Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 8, Mar 22, Apr 5, More...

Norwegian Cruise Line (NCL), NCL Norwegian Luna

13 Night - Repo - Transatlantic
Starting in Civitavecchia Rome, Italy, Barcelona, Spain, Gibraltar, Miami, Fl
2026 Sails: Mar 10, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Tunis Gulf, Palermo (Sicily)
2026 Sails: Mar 12, Mar 19, Mar 26, Apr 2, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Mar 13, Mar 20, Mar 27, Apr 3, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Mar 14, Mar 21, Mar 28, Apr 4, More...

Princess Cruises, Sapphire Princess

7 Night - Mediterranean with Greece & Italy
Starting in Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 15, Mar 29, Apr 12, More...

Princess Cruises, Sapphire Princess

14 Night - Mediterranean with Greece, Italy & Croatia
Starting in Civitavecchia (for Rome), Italy, Sarande, Albania, Katakolon (for Olympia), Greece, Valletta, Malta, Sicily (Catania), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Mar 15, Mar 29, More...

Silversea Cruises, Silver Muse

10 Night - Civitavecchia to Athens
Starting in Civitavecchia (Rome), Salerno, Palermo, Sicily, Gythion, Heraklion, Rhodes, Alexandria EG, Athens (Piraeus)
2026 Sails: Mar 15, More...

Viking Ocean, Viking Mars

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Mar 16, 2028: Mar 14, More...

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