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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Viking Ocean, Viking Vela
Viking Vela7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 7, More...
MSC Cruises, MSC World Asia
MSC World Asia7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy
2026 Sails: Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, More...
Viking Ocean, Viking Neptune
Viking Neptune7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 8, More...
MSC Cruises, MSC Magnifica
MSC Magnifica10 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Malaga (Granada), Spain, Alicante, Spain, Civitavecchia (Rome), Italy
2026 Sails: Dec 15, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica4 Night - Mediterranean Roundtrip from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: Dec 16, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Mediterranean Roundtrip from Savona
Starting in Savona, Naples, Palermo, La Goulette (Tunis), Barcelona, Marseille, Savona
2026 Sails: Dec 20, Dec 27, 2027: Jan 3, Feb 14, Feb 21, Feb 28, Mar 7, Mar 14, Mar 21, More...
Viking Ocean, Viking Libra
Viking Libra7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sail the Mediterranean Sea, Barcelona
2026 Sails: Dec 20, More...
Regent Seven Seas, Seven Seas Navigator
Seven Seas Navigator14 Night - Spice Trail Sail
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Cruising the Mediterranean Sea, Alexandria EG, Cruising the Mediterranean Sea, Limassol, Rhodes, Heraklion (Crete), Kusadasi, Athens (Piraeus)
2026 Sails: Dec 21, More...
Azamara Onward7 Night - Mediterranean Holiday Cruise : Florence, Mahon & Palma
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona
2026 Sails: Dec 22, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Amalfi Coast, Africa & Iberia
Starting in Rome (Civitavecchia), Naples, Scenic Sailing Stromboli, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2026 Sails: Dec 23, More...

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Italy Cruise Departures