Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Magnifica

5 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Nov 8, More...

MSC Cruises, MSC World Europa

6 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 8, More...

Regent Seven Seas, Seven Seas Grandeur

14 Night - New World Passage
Starting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami
2026 Sails: Nov 8, More...

Regent Seven Seas, Seven Seas Grandeur

21 Night - Atlantic Ocean Isles
Starting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami, Cruising the Caribbean Sea, Roatan, Santo Tomas De Castilla, Harvest Caye, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2026 Sails: Nov 8, More...

MSC Cruises, MSC World Europa

6 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Nov 9, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 10, More...

MSC Cruises, MSC Splendida

23 Night - Msc Grand Voyages
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 10, More...

Princess Cruises, Enchanted Princess

23 Night - Mediterranean, Aegean & Moroccan Passage
Starting in Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy, Mallorca (Palma), Spain, Gibraltar, Casablanca, Morocco (for Marrakesh), Santa Cruz de Tenerife, La Palma, Canary Islands, Spain, Fort Lauderdale, Florida
2026 Sails: Nov 10, More...

Regent Seven Seas, Seven Seas Voyager

17 Night - Ancient & Historic Shores
Starting in Venice (Trieste), Split, Dubrovnik, Croatia, Kotor, Cruising the Ionian Sea, Katakolon, Mykonos, Athens (Piraeus), Cruising the Adriatic Sea, Split, Cruising the Ionian Sea, Heraklion (Crete), Mykonos, Kusadasi, Mytilini (Lesbos), Cruising the Aegean Sea, Istanbul
2026 Sails: Nov 10, More...

Regent Seven Seas, Seven Seas Voyager

7 Night - Path of the Ancients
Starting in Venice (Trieste), Split, Dubrovnik, Croatia, Kotor, Cruising the Ionian Sea, Katakolon, Mykonos, Athens (Piraeus)
2026 Sails: Nov 10, More...

<= Back