Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Silversea, Silver Muse

14 Night - Fusina to Lisbon
Starting in Fusina (Venice), Piran, Zadar, Hvar, Dubrovnik, Croatia, Giardini Naxos (Sicily), Valletta, Trapani, Sicily, Cagliari (Sardinia), Cartagena ES, Spain, Malaga (Costa del Sol), Lisbon
2026 Sails: Oct 7, More...

Silversea, Silver Muse

7 Night - Fusina to Valletta
Starting in Fusina (Venice), Piran, Zadar, Hvar, Dubrovnik, Croatia, Giardini Naxos (Sicily), Valletta
2026 Sails: Oct 7, More...

Viking Ocean, Viking Sky

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Chioggia), Zadar, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Oct 7, More...

Windstar, Wind Surf

8 Night - James Beard Foundation & Wine Cruise : Classic Italy & Dalmatian Coast
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Trogir, Croatia, Rovinj, Venice
2026 Sails: Oct 7, More...

Windstar Tours, Wind Surf Tours

12 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Trogir, Croatia, Rovinj, Venice, Venice, Italy, Cernobbio
2026 Sails: Oct 7, More...

Costa Cruise Lines, Costa Diadema

10 Night - Mediterranean Roundtrip from Savona
Starting in Savona, Italy, Barcelona, Spain, Tangier, Morocco, Casablanca, Morocco, Cadiz, Spain, Gibraltar (UK), Malaga, Spain, Marseille, France, Savona, Italy
2026 Sails: Oct 8, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Cagliari, Italy, Palermo (Sicily)
2026 Sails: Oct 8, Oct 15, More...

Riviera River, MS Douro Elegance

14 Night - Grand Tour of the Heart of Italy to Portugal's Douro Valley Cruise
Starting in Perugia, Italy, Umbria, Italy, Spoleto, Italy, Marche, Italy, Orvieto, Italy, Porto, Portugal, Pinhao, Portugal, Castelo Rodrigo, Portugal, Salamanca, Spain, Mateus Palace, Portugal, Lamego, Portugal, Porto, Portugal
2026 Sails: Oct 8, 2027: Jul 1, Aug 19, Aug 26, Sep 30, More...

Silversea, Silver Spirit

10 Night - Civitavecchia to Fusina
Starting in Civitavecchia (Rome), Naples, Amalfi, Giardini Naxos (Sicily), Valletta, Kotor, Split, Zadar, Rovinj, Fusina (Venice)
2026 Sails: Oct 8, More...

Avalon Waterways Tours, Avalon Envision Tours

25 Night - Vineyards, Chateaux & Bordeaux with Swiss Alps, in Lake Como & in Lucerne
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation) Paris, France (Embarkation), Vernon, Caudebec, Caudebec Excursion to Normandy, Rouen, Conflans, Paris, Paris (Disembarkation) Bordeaux (Embarkation), Bordeaux / Pauillac, Cussac Fort Medoc, Blaye / Bourg, Libourne Excursion to Saint-emilion, Bordeaux, Bordeaux Excursion to Arcachons Bay, Bordeaux (Disembarkation)
2026 Sails: Oct 9, More...

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