Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Smeralda

5 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Civitavecchia (Rome)
2026 Sails: Nov 6, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Nov 6, Nov 13, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Cagliari, Palermo, Civitavecchia (Rome)
2026 Sails: Nov 7, More...

Costa Cruise Lines, Costa Smeralda

5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Civitavecchia (Rome), Savona
2026 Sails: Nov 7, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 7, More...

Oceania Cruises, Oceania Allura

Deal link -> Special

25 Night - Allura Autumn Crossing
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona, Malaga, Agadir, Arrecife (Lanzarote), San Juan, Miami
2026 Sails: Nov 7, More...

Oceania Cruises, Oceania Allura

Deal link -> Special

10 Night - Artists & Aristocrats
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona
2026 Sails: Nov 7, More...

Viking Ocean, Viking Saturn

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Nov 7, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Cagliari, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Nov 8, More...

MSC Cruises, MSC Magnifica

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 8, Nov 15, Nov 22, Nov 29, More...

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