Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Princess Tours, Sun Princess Tours

27 Night - Classic Italy - Tour 4C
Starting in Venice, Italy, Florence, Italy, Rome, Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Barcelona, Spain, Ibiza, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 20, More...

Cunard Line, Queen Victoria

25 Night - Istanbul, Greek Islands and Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Souda Bay (for Chania), Crete, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Civitavecchia (tours to Rome), Italy, Palma De Mallorca, Spain, Cartagena ES, Malaga (tours to Granada), Spain, Lisbon, Portugal, La Coruna (tours to Santiago de Compostela), Spain, Southampton, England, UK
2026 Sails: Sep 21, More...

Cunard Line, Queen Victoria

7 Night - Istanbul and Greek Islands
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: Sep 21, More...

Cunard Line, Queen Victoria

14 Night - Istanbul and Greek Islands
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Rhodes, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Souda Bay (for Chania), Crete, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Civitavecchia (tours to Rome), Italy
2026 Sails: Sep 21, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Croatia & the Adriatic
Starting in Ravenna, Italy, Trieste, Italy, Split, Croatia, Dubrovnik, Croatia, Sarande, Albania, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Sep 21, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Italian Riviera & France
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Florence / Pisa (La Spezia), Italy, Portofino, Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Sep 22, More...

Crystal Cruises, Crystal Serenity

9 Night - Europe & Mediterranean
Starting in Civitavecchia (Rome), Livorno (Tuscany), Portofino, Ile Rousse, Corsica, Monte Carlo, Sete, Porto Mahon, Barcelona
2026 Sails: Sep 22, More...

Ritz-Carlton, Ilma

6 Night - Venice / Rome (Civitavecchia)
Starting in Venice, Zadar, Dubrovnik, Croatia, Kotor, Sorrento, Rome (Civitavecchia)
2026 Sails: Sep 22, More...

Sea Cloud, Sea Cloud II

11 Night - Proud Cities Along the Adriatic Coast
Starting in Venice, Rovinj, Zadar, Trogir, Korcula, Dubrovnik, Croatia, Otranto, Pozzallo / Sicily, Catania / Sicily
2026 Sails: Sep 22, More...

Costa Cruise Lines, Costa Diadema

4 Night - Mediterranean Roundtrip from Savona
Starting in Savona, Italy, Palma De Mallorca, Spain, Marseille, France, Savona, Italy
2026 Sails: Sep 23, More...

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