Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Norwegian Cruise Line, Norwegian Viva

9 Night - Greek Isles & Italy
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Valletta, Malta, Santorini Island, Greece, Piraeus / Athens, Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: Jul 22, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Jul 23, Sep 24, More...

Explora Journeys, EXPLORA III

5 Night - A Mediterranean Prelude To
Starting in Genoa, Marseille, Saint-Tropez, Villefranche-Sur-Mer (Nice), Livorno (Florence), Civitavecchia (Rome)
2026 Sails: Jul 24, More...

Ritz-Carlton, Ilma

7 Night - Rome (Civitavecchia) / Rome (Civitavecchia)
Starting in Rome (Civitavecchia), Valletta, Trapani, Palermo, Sicily, Amalfi, Sorrento, Rome (Civitavecchia)
2026 Sails: Jul 24, More...

Windstar, Wind Surf

16 Night - Star Collector : Southern Italian Enchantment & Balkan Beaches
Starting in Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome, Amalfi, Marina Velentia (Vibo Valentia), Italy, Reggio Calabria, Italy, Taranto, Italy, Otranto, Italy, Rab, Croatia, Venice
2026 Sails: Jul 24, More...

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean with Total Solar Eclipse
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain, Gibraltar, Cartagena ES, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jul 25, More...

Royal Caribbean, Legend of the Seas

8 Night - Western Mediterranean
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Palma De Mallorca, Spain, Alicante, Spain, Malaga, Spain, Barcelona, Spain
2026 Sails: Jul 25, More...

SeaDream Yacht Club, SeaDream I

7 Night - Cruise from Rome (Civitavecchia) to Valletta
Starting in Rome (Civitavecchia), Porto Ercole, Bonifacio, Corsica, Ponza, Amalfi, Capri, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Jul 25, More...

Holland America, Oosterdam

14 Night - Italy, French Riviera & Spain Collectors' Voyage
Starting in Civitavecchia (Rome), Italy, Livorno (Florence / Pisa), Italy, Portofino, Italy, Marseille (Provence), France, Gibraltar, Barcelona, Spain, Ibiza, Spain, Alicante, Spain, Malaga, Spain, Tangier, Morocco, Lisbon, Portugal
2026 Sails: Jul 26, More...

Holland America, Oosterdam

27 Night - Solar Eclipse Collectors' Voyage : Italy & Iberia
Starting in Civitavecchia (Rome), Italy, Livorno (Florence / Pisa), Italy, Portofino, Italy, Marseille (Provence), France, Gibraltar, Barcelona, Spain, Ibiza, Spain, Alicante, Spain, Malaga, Spain, Tangier, Morocco, Lisbon, Portugal, Alicante, Spain, Barcelona, Spain, Ajaccio, Corsica, France, Civitavecchia (Rome), Italy, Bari (Puglia), Italy, Kotor, Montenegro, Scenic cruising Bay of Kotor, Piraeus (Athens), Greece
2026 Sails: Jul 26, More...

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