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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC Magnifica
MSC Magnifica5 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Oct 29, Nov 3, More...
MSC Cruises, MSC Opera
MSC Opera25 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Tangier (Tetouan), Morocco, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, La Romana, Dominican Republic, Catalina Island, Dominican Republic, Bridgetown, Barbados, Fort-de-France, Martinique, Pointe-A-Pitre, Guadeloupe, Road Town (Tortola), British Virgin Islands, La Romana, Dominican Republic
2026 Sails: Oct 29, More...
MSC Cruises, MSC Opera
MSC Opera4 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Oct 29, More...
MSC Cruises, MSC Opera
MSC Opera18 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Tangier (Tetouan), Morocco, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, La Romana, Dominican Republic
2026 Sails: Oct 29, More...
MSC Cruises, MSC Opera
MSC Opera3 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Livorno (Florence), Italy, Marseille (Provence), France
2026 Sails: Oct 29, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia3 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Tarragona, Spain
2026 Sails: Oct 29, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia5 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 29, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia4 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Tarragona, Spain, Marseille (Provence), France
2026 Sails: Oct 29, More...
Celebrity Cruises, Celebrity Ascent
Celebrity Ascent14 Night - Italy & Bermuda Transatlantic
Starting in Rome (Civitavecchia), Italy, Cagliari, Sardinia, Italy, Malaga, Spain, Madeira (Funchal), Portugal, Royal Naval Dockyard, Bermuda, Fort Lauderdale, Florida
2026 Sails: Oct 30, More...
MSC Armonia2 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Oct 30, 2027: Oct 8, More...

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Italy Cruise Departures