Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Viking Ocean, Viking Sea

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona (Tarragona)
2026 Sails: Sep 15, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Palermo
Starting in Palermo, Napoli, Civitavecchia (Rome), Ajaccio, Savona
2026 Sails: Sep 16, More...

Norwegian Cruise Line, Norwegian Viva

Deal link -> Special

10 Night - Greek Isles & Italy
Starting in Civitavecchia Rome, Italy, Livorno / Florence / Pisa, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Heraklion / Crete, Greece, Mykonos, Greece, Piraeus / Athens, Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: Sep 16, More...

Sea Cloud, Sea Cloud Spirit

9 Night - Luxury Lifestyle, Relaxing Beats Series
Starting in Livorno, Calvi / Corsica, Portoferraio / Elba, Viareggio, Portofino, San Remo, St Tropez, Nice
2026 Sails: Sep 16, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Cruise from Naples to Savona
Starting in Napoli, Civitavecchia (Rome), Ajaccio, Savona
2026 Sails: Sep 17, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Mediterranean from Naples to Marseille
Starting in Napoli, Civitavecchia (Rome), Ajaccio, Savona, Marseille
2026 Sails: Sep 17, More...

Costa Cruise Lines, Costa Fascinosa

15 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Ajaccio, Savona, Marseille, Barcelona, Palma De Mallorca, Malta / La Valletta, Santorini, Mykonos, Athens (Piraeus), Souda Bay, Messina (Taormina), Civitavecchia (Rome)
2026 Sails: Sep 18, More...

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Santorini, Mykonos, Argostoli / Cephalonia, Marghera, Bari, Corfu, Zakynthos, Argostoli / Cephalonia, Dubrovnik, Croatia, Split, Trieste
2026 Sails: Sep 19, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome)
2026 Sails: Sep 19, Sep 26, More...

Star Clippers, Star Clipper

11 Night - Rome to Athens
Starting in Civitavecchia (Port for Rome), Italy, Ponza / Pontine Islands, Italy, Palmarola / Pontine Islands, Italy, Sorrento, Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Taormina, Sicily, Italy, Syracuse IT, Sicily, Italy, Katakolon, Greece, Gythio, Greece, Monemvasia, Greece, Hydra, Greece, Piraeus (Port of Athens), Greece
2026 Sails: Sep 19, More...

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