Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Cunard Line, Queen Victoria

7 Night - Italy, France and Spain
Starting in Civitavecchia (tours to Rome), Italy, Livorno (tours to Florence or Pisa), Italy, La Seyne-sur-Mer (for Toulon), France, Calvi, Corsica, France, Valencia, Spain, Barcelona, Spain
2026 Sails: Jul 20, More...

Cunard Line, Queen Victoria

14 Night - Adriatic and Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Livorno (tours to Florence or Pisa), Italy, La Seyne-sur-Mer (for Toulon), France, Calvi, Corsica, France, Valencia, Spain, Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy
2026 Sails: Jul 20, More...

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Civitavecchia (tours to Rome), Italy, Livorno (tours to Florence or Pisa), Italy, La Seyne-sur-Mer (for Toulon), France, Calvi, Corsica, France, Valencia, Spain, Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Naples (tours to Capri or Pompeii), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Jul 20, More...

Explora Journeys, EXPLORA II

14 Night - An Extended Journey of Sunlit Shores & Quiet Seas
Starting in Fusina (Venice), Rovinj, Dubrovnik, Croatia, Brindisi, Kotor, Milos, Piraeus (Athens), Bari, Nydri, Lefkada, Pylos, Katapola, Mykonos, Piraeus (Athens)
2026 Sails: Jul 20, Sep 21, More...

Norwegian Line Tours, Norwegian Viva Tours

11 Night - Rome & Etruria Pre Cruisetour
Starting in At Hotel, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Valletta, Malta, Santorini Island, Greece, Piraeus / Athens, Greece, Kusadasi, Turkey, Istanbul, Turkey
2026 Sails: Jul 20, More...

Regent Seven Seas, Seven Seas Splendor

8 Night - History & Romance
Starting in Venice (Trieste), Rijeka, Zadar, Dubrovnik, Croatia, Bari, Igoumenitsa, Kotor, Cruising the Mediterranean Sea, Athens (Piraeus)
2026 Sails: Jul 20, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Venice (Chioggia), Split, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Ionian Sea, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Barcelona
2026 Sails: Jul 20, More...

Silversea, Silver Muse

10 Night - Fusina to Civitavecchia
Starting in Fusina (Venice), Zadar, Split, Dubrovnik, Croatia, Bari, Kotor, Giardini Naxos (Sicily), Palermo, Sicily, Naples, Civitavecchia (Rome)
2026 Sails: Jul 21, More...

Viking Ocean, Viking Sea

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Jul 21, Oct 16, More...

Windstar Tours, Wind Surf Tours

11 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Cernobbio, Venice, Italy, Venice, Rovinj, Split, Dubrovnik, Croatia, Kotor, Giardini Naxos, Sorrento, Rome
2026 Sails: Jul 21, Aug 15, More...

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