Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Meraviglia

24 Night - Msc Grand Voyages
Starting in Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Ponta Delgada (Azores), Portugal, Boston, New York City (Brooklyn), New York, Miami, Florida
2026 Sails: Oct 18, More...

Silversea, Silver Ray

11 Night - Civitavecchia to Barcelona
Starting in Civitavecchia (Rome), Giardini Naxos (Sicily), Valletta, Tunis (La Goulette), Trapani, Sicily, Cagliari (Sardinia), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Oct 18, More...

Silversea, Silver Spirit

10 Night - Fusina to Athens
Starting in Fusina (Venice), Koper, Rijeka, Dubrovnik, Croatia, Bari, Corfu, Katakolon (Olympia), Gythion, Souda Bay (Crete), Athens (Piraeus)
2026 Sails: Oct 18, More...

Silversea, Silver Spirit

20 Night - Europe from Fusina to Athens
Starting in Fusina, Koper, Rijeka, Dubrovnik, Croatia, Bari, Corfu, Katakolon, Gythion, Souda Bay, Athens, Mykonos, Volos, Thessaloniki, Istanbul, Rhodes, Santorini, Athens
2026 Sails: Oct 18, More...

Celebrity Cruises, Celebrity Eclipse

11 Night - Adriatic & Greek Isles Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Valletta, Malta, Mykonos, Greece, Santorini, Greece, Rhodes, Greece, Athens (Piraeus), Greece
2026 Sails: Oct 19, More...

MSC Cruises, MSC Grandiosa

Deal link -> Special

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 19, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Croatia & Malta Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Valletta, Malta, Dubrovnik, Croatia, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 19, More...

Princess Cruises, Enchanted Princess

11 Night - Mediterranean with Greek Isles & Italy
Starting in Civitavecchia (for Rome), Italy, Sardinia (Alghero), Italy, Genoa (for Cinque Terre), Italy, Livorno (for Florence / Pisa), Italy, Valletta, Malta, Sicily (Messina), Italy, Mykonos, Greece, Rhodes, Greece, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece
2026 Sails: Oct 20, More...

Princess Cruises, Enchanted Princess

21 Night - The Best of the Mediterranean
Starting in Civitavecchia (for Rome), Italy, Sardinia (Alghero), Italy, Genoa (for Cinque Terre), Italy, Livorno (for Florence / Pisa), Italy, Valletta, Malta, Sicily (Messina), Italy, Mykonos, Greece, Rhodes, Greece, Kusadasi, Turkey (for Ephesus), Athens (Piraeus), Greece, Santorini, Greece, Crete (Chania), Greece, Katakolon (for Olympia), Greece, Corfu, Greece, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Oct 20, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Cagliari
Starting in Cagliari, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona, Cagliari
2026 Sails: Oct 21, Oct 28, More...

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