Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Meraviglia

26 Night - Msc Grand Voyages
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Ponta Delgada (Azores), Portugal, Boston, New York City (Brooklyn), New York, Miami, Florida
2026 Sails: Oct 16, More...

Norwegian Line Tours, Norwegian Gem Tours

9 Night - Rome & Etruria Pre Cruisetour
Starting in At Hotel, Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Corfu, Greece, Kotor, Montenegro, Zadar, Croatia, Venice (Trieste), Italy, Venice (Ravenna), Italy
2026 Sails: Oct 16, More...

Viking Ocean, Viking Sea

Deal link -> Special

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: Oct 16, More...

MSC Cruises, MSC Magnifica

4 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Genoa (Portofino), Italy
2026 Sails: Oct 17, Oct 21, Oct 25, 2028: Apr 29, More...

MSC Cruises, MSC Magnifica

1 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France
2026 Sails: Oct 17, 2027: Oct 20, More...

MSC Cruises, MSC Magnifica

2 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Oct 17, More...

MSC Cruises, MSC Meraviglia

25 Night - Msc Grand Voyages
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Ponta Delgada (Azores), Portugal, Boston, New York City (Brooklyn), New York, Miami, Florida
2026 Sails: Oct 17, More...

Regent Seven Seas, Seven Seas Voyager

7 Night - Mediterranean Discovery
Starting in Venice (Fusina), Rijeka, Split, Kotor, Cruising the Ionian Sea, Gythion, Mykonos, Athens (Piraeus)
2026 Sails: Oct 17, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Croatia Cruise
Starting in Ravenna, Italy, Dubrovnik, Croatia, Santorini, Greece, Athens (Piraeus), Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 17, More...

SeaDream Yacht Club, SeaDream I

7 Night - Southern Italy Dream Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Porto Cervo, Sardinia, Positano, Amalfi, Lipari, Aeolian Islands, Taormina (Mount Etna) Sicily, Valletta
2026 Sails: Oct 17, More...

<= Back

More =>