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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Costa Cruise Lines, Costa Toscana
Costa Toscana8 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca, Alicante, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Nov 20, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa3 Night - Europe from Bari to Rome (Civitavecchia)
Starting in Bari, Italy, Corfu, Greece, Civitavecchia / Rome
2026 Sails: Nov 21, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica5 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Civitavecchia (Rome)
2026 Sails: Nov 21, More...
MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Nov 21, Nov 28, Dec 5, Dec 12, Dec 19, Dec 26, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Civitavecchia (Rome), Savona
2026 Sails: Nov 22, More...
MSC Cruises, MSC Magnifica
MSC Magnifica7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 22, Nov 29, More...
Oceania Cruises, Oceania Sirena
Oceania Sirena10 Night - Croatia & Italy Holiday
Starting in Venice (Fusina), Koper, Rijeka, Split, Bari, Corfu, Crotone (Calabria), Valletta, Messina (Sicily), Naples / Pompeii, Rome (Civitavecchia)
2026 Sails: Nov 22, More...
Silversea, Silver Nova
Silver Nova7 Night - Civitavecchia to Barcelona
Starting in Civitavecchia (Rome), Naples, Trapani, Sicily, Tunis (La Goulette), Cagliari (Sardinia), Palma De Mallorca, Barcelona
2026 Sails: Nov 23, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa66 Night - Round World from Civitavecchia (Rome)
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU
2026 Sails: Nov 24, More...
Costa Cruise Lines, Costa Deliziosa
Costa Deliziosa40 Night - Round World from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco
2026 Sails: Nov 24, More...

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Italy Cruise Departures