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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Viking Ocean, Viking Saturn
Viking Saturn Cruises12 Night - Mediterranean Odyssey
Starting in Venice (Fusina), Split, Dubrovnik, Croatia, Corfu (Kerkyra), Sail the Strait of Messina, Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Barcelona
2026 Sails: Jan 5, More...
MSC Cruises, MSC Splendida
MSC Splendida Cruise Ship4 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Jan 6, Apr 21, More...
MSC Cruises, MSC Orchestra
MSC Orchestra Cruise Ship7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy
2026 Sails: Jan 7, Jan 14, Jan 21, Jan 28, Feb 4, Feb 11, Feb 18, Feb 25, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, Apr 8, Apr 15, More...
MSC Cruises, MSC Splendida
MSC Splendida Cruise Ship3 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Jan 7, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Palermo (Sicily)
2026 Sails: Jan 8, Jan 15, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Jan 9, Jan 16, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda Cruises6 Night - Europe from Savona to Rome (Civitavecchia)
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Jan 10, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana Cruises12 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Naples, Italy, Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Alicante, Spain, Malaga, Spain, Tangier, Morocco, Alboran Sea Darkest Spot, La Goulette, Tunisia, Palermo (Sicily)
2026 Sails: Jan 11, More...
MSC Cruises, MSC World Europa
MSC World Europa Cruises7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, Apr 12, More...
Viking Ocean, Viking Star
Viking Star Cruises7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Jan 11, More...

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Italy Cruise Departures