Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Pacifica

3 Night - Western Mediterranean from Rome (Civitavecchia) to Barcelona
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Oct 3, More...

Costa Cruise Lines, Costa Pacifica

2 Night - Southern Europe from Rome (Civitavecchia) to Marseille
Starting in Civitavecchia (Rome), Savona, Marseille
2026 Sails: Oct 3, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Oct 3, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Oct 3, Oct 12, Oct 21, Oct 30, Nov 8, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Oct 3, Oct 10, Oct 17, 2027: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: Oct 3, Oct 10, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Bari, Italy, Santorini, Greece, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Cefalonia / Argostoli, Greece, Corfu, Greece, Bari, Italy
2026 Sails: Oct 3, Oct 10, Oct 17, More...

Oceania Cruises, Oceania Allura

7 Night - Mediterranean Melange
Starting in Trieste, Ravenna, Rijeka, Split, Brindisi, Corfu, Gythion, Athens (Piraeus)
2026 Sails: Oct 3, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greek Isles Cruise
Starting in Ravenna, Italy, Santorini, Greece, Athens (Piraeus), Greece, Mykonos, Greece, Split, Croatia, Ravenna, Italy
2026 Sails: Oct 3, More...

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