Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome)
2026 Sails: Aug 20, Aug 27, More...

PONANT, Le Bougainville

7 Night - Natural Wonders and Cultural Jewels of Dalmatia
Starting in Venice, Rovinj, Zadar, Primosten, Split, Hvar, Korcula, Mljet, Tivat, Dubrovnik, Croatia
2026 Sails: Aug 20, More...

Royal Caribbean, Legend of the Seas

7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 20, More...

Star Clippers, Star Clipper

16 Night - Grand Voyage : Venice to Rome
Starting in Venice, Italy, Mali Losinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Otranto, Italy, Taormina, Sicily, Italy, Lipari / Aeolian Islands, Italy, Amalfi, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Amalfi, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Aug 20, More...

Star Clippers, Star Clipper

11 Night - Italy, Montenegro, Croatia
Starting in Venice, Italy, Mali Losinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Otranto, Italy, Taormina, Sicily, Italy, Lipari / Aeolian Islands, Italy, Amalfi, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Aug 20, More...

Celebrity Cruises, Celebrity Constellation

10 Night - Best of Italy & Croatia Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Sicily (Messina), Italy, Amalfi Coast (Salerno), Italy, Portofino, Italy, Florence / Pisa (Livorno), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 21, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Aug 21, Aug 28, More...

MSC Cruises, MSC Divina

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, 2027: Jun 25, Jul 23, Jul 30, Aug 20, Sep 3, Sep 17, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, More...

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