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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Syracuse : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC Lirica
MSC Lirica7 Night - Mediterranean
Starting in Bari, Italy, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Feb 21, Feb 28, Mar 7, Mar 14, 2027: Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, More...
MSC Cruises, MSC Splendida
MSC Splendida7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Feb 24, Mar 3, Mar 17, Mar 24, Mar 31, Apr 7, Apr 14, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy
2026 Sails: Feb 24, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Apr 7, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana2 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona
2026 Sails: Mar 1, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Civitavecchia, Genoa
2026 Sails: Mar 1, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana4 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Civitavecchia
2026 Sails: Mar 1, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, Apr 12, More...
MSC Cruises, MSC Splendida
MSC Splendida7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, Apr 13, More...
MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Apr 7, Apr 14, More...

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Italy Cruise Departures