Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Ritz-Carlton, Evrima

7 Night - Rome (Civitavecchia) / Nice
Starting in Rome (Civitavecchia), Portoferraio, Elba, Livorno, Monte Carlo, Ajaccio, Corsica, Calvi, Corsica, Nice
2026 Sails: May 20, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Calanques national park bay, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Ibiza bay, Palermo (Sicily)
2026 Sails: May 21, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Napoli, Civitavecchia (Rome)
2026 Sails: May 21, May 28, Jul 23, Jul 30, Aug 6, More...

MSC Cruises, MSC Divina

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy
2026 Sails: May 21, Jun 4, Jun 18, Jun 25, Jul 9, Jul 16, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 24, Oct 8, Oct 15, Oct 22, 2027: Jun 24, Jul 22, Aug 19, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: May 21, Jul 23, Sep 24, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy
2026 Sails: May 21, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, Oct 22, Oct 29, Nov 5, More...

Windstar, Wind Surf

10 Night - Sicilian Splendors
Starting in Rome, Syracuse IT, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome
2026 Sails: May 21, More...

Windstar, Wind Surf

13 Night - Historic Harbors of Italy & Beyond
Starting in Rome, Syracuse IT, Italy, Valletta, Gozo, Porto Empedocle, Trapani, Lipari, Sorrento, Amalfi, Rome, Porto Venere, Bonifacio, France, Rome
2026 Sails: May 21, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: May 22, More...

Costa Cruise Lines, Costa Smeralda

3 Night - Western Mediterranean from Rome (Civitavecchia) to Barcelona
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: May 22, More...

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