Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome)
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Jul 4, Sep 26, More...

Emerald Cruises, Emerald Kaia

7 Night - Adriatic Discovery : Venice, Istria & the Croatian Archipelago
Starting in Venice, Italy, Piran, Slovenia, Mali Losinj, Croatia, Senj, Croatia / Baska, Krk Island, Croatia, Opatija, Croatia, Rovinj, Croatia, Venice, Italy
2026 Sails: Jul 4, Jul 25, 2027: Jun 5, More...

Emerald Cruises, Emerald Kaia

14 Night - Discover the Gems of Italy & Croatia
Starting in Venice, Italy, Piran, Slovenia, Mali Losinj, Croatia, Senj, Croatia / Baska, Krk Island, Croatia, Opatija, Croatia, Rovinj, Croatia, Venice, Italy, Rovinj, Croatia, Sibenik, Croatia, Trogir, Croatia, Vis / Hvar, Croatia, Hvar, Croatia, Korcula, Croatia, Dubrovnik, Croatia
2026 Sails: Jul 4, Jul 25, More...

Emerald Cruises, Emerald Sakara

7 Night - Enchanting Italian Coastlines
Starting in Civitavecchia (Rome), Italy, Amalfi, Italy / Capri, Italy, Capri, Italy / Sorrento, Italy, Sorrento, Italy, Gaeta, Italy, Porto Cervo, Italy, Bonifacio, France, Civitavecchia (Rome), Italy
2026 Sails: Jul 4, Aug 8, 2027: Aug 28, More...

MSC Cruises, MSC Fantasia

Deal link -> Special

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jul 4, Jul 13, Jul 31, Aug 9, Aug 27, Sep 5, Sep 14, Oct 2, Oct 11, Oct 20, Oct 29, Nov 7, More...

MSC Cruises, MSC Lirica

Deal link -> Special

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy, Venice / Marghera, Italy
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, 2027: Apr 10, Apr 17, Apr 24, May 1, May 8, May 15, May 22, May 29, More...

MSC Cruises, MSC Meraviglia

Deal link -> Special

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: Jul 4, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Bari, Italy, Santorini, Greece, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Cefalonia / Argostoli, Greece, Corfu, Greece, Bari, Italy
2026 Sails: Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...

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