Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Crystal Cruises, Crystal Serenity

9 Night - Europe & Mediterranean
Starting in Civitavecchia (Rome), Livorno (Tuscany), Portofino, Ile Rousse, Corsica, Monte Carlo, Sete, Porto Mahon, Barcelona
2026 Sails: Sep 22, More...

Ritz-Carlton, Ilma

6 Night - Venice / Rome (Civitavecchia)
Starting in Venice, Zadar, Dubrovnik, Croatia, Kotor, Sorrento, Rome (Civitavecchia)
2026 Sails: Sep 22, More...

Sea Cloud, Sea Cloud II

10 Night - Proud Cities Along the Adriatic Coast
Starting in Venice, Rovinj, Zadar, Trogir, Korcula, Dubrovnik, Croatia, Otranto, Pozzallo / Sicily, Catania / Sicily
2026 Sails: Sep 22, More...

Viking Ocean, Viking Vesta

Deal link -> Special

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Sep 22, Nov 18, More...

Costa Cruise Lines, Costa Diadema

4 Night - Mediterranean Roundtrip from Savona
Starting in Savona, Italy, Palma De Mallorca, Spain, Marseille, France, Savona, Italy
2026 Sails: Sep 23, More...

Holland America, Oosterdam

10 Night - Adriatic Allure : Croatia, Greek Isles & Istanbul
Starting in Trieste (Venice), Italy, Rijeka, Croatia, Split, Croatia, Thira (Santorini), Greece, Bodrum, Turkey, Kusadasi (Ephesus), Turkey, Istanbul, Turkey, Cruising the Dardanelles, Piraeus (Athens), Greece
2026 Sails: Sep 23, More...

Holland America, Oosterdam

21 Night - Croatia, Greece & Istanbul Collectors' Voyage
Starting in Trieste (Venice), Italy, Rijeka, Croatia, Split, Croatia, Thira (Santorini), Greece, Bodrum, Turkey, Kusadasi (Ephesus), Turkey, Istanbul, Turkey, Cruising the Dardanelles, Piraeus (Athens), Greece, Nafplion, Greece, Istanbul, Turkey, Kusadasi (Ephesus), Turkey, Thira (Santorini), Greece, Rhodes, Greece, Souda (Chania), Greece, Piraeus (Athens), Greece
2026 Sails: Sep 23, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Palermo (Sicily)
2026 Sails: Sep 24, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome)
2026 Sails: Sep 24, More...

Norwegian Line Tours, Norwegian Gem Tours

10 Night - Pre Venice Cruisetour
Starting in At Hotel, Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Olympia / Katakolon, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Sep 24, More...

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