Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Explora Journeys, EXPLORA II

8 Night - A Journey Across Mediterranean Icons and Moroccan Shores
Starting in Civitavecchia (Rome), Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona, Gibraltar, Casablanca
2026 Sails: Dec 5, More...

Viking Ocean, Viking Saturn

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 5, More...

MSC Cruises, MSC Magnifica

10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Cadiz (Seville), Spain, Casablanca (Marrakesh), Morocco, Malaga (Granada), Spain, Alicante, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Dec 6, Dec 16, 2027: Dec 26, More...

MSC Cruises, MSC World Asia

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Dec 6, Dec 13, Dec 20, Dec 27, 2027: Jan 3, Jan 10, Jan 17, Jan 24, Jan 31, Feb 7, Feb 14, Feb 21, Feb 28, Mar 7, Mar 14, Mar 21, Mar 28, Apr 4, Apr 11, More...

MSC Cruises, MSC Fantasia

11 Night - Canary Islands and Madeira
Starting in Civitavecchia (Rome), Italy, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de La Palma, Santa Cruz de Tenerife, Puerto Del Rosario / Fuerteventura, Spain, Funchal (Madeira Islands), Portugal, Arrecife De Lanzarote (Canary Islands), Spain, Las Palmas de Gran Canaria (Canary Islands), Spain
2026 Sails: Dec 7, More...

MSC Cruises, MSC Fantasia

8 Night - Canary Islands and Madeira
Starting in Civitavecchia (Rome), Italy, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de La Palma, Santa Cruz de Tenerife, Puerto Del Rosario / Fuerteventura, Spain, Funchal (Madeira Islands), Portugal
2026 Sails: Dec 7, More...

MSC Cruises, MSC Fantasia

6 Night - Canary Islands and Madeira
Starting in Civitavecchia (Rome), Italy, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de La Palma, Santa Cruz de Tenerife
2026 Sails: Dec 7, More...

MSC Cruises, MSC Fantasia

10 Night - Canary Islands and Madeira
Starting in Civitavecchia (Rome), Italy, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de La Palma, Santa Cruz de Tenerife, Puerto Del Rosario / Fuerteventura, Spain, Funchal (Madeira Islands), Portugal, Arrecife De Lanzarote (Canary Islands), Spain
2026 Sails: Dec 7, More...

MSC Cruises, MSC Lirica

10 Night - Mediterranean
Starting in Venice / Marghera, Italy, Katakolon (Olympia), Greece, Heraklion (Crete), Greece, Port Said, Egypt, Alexandria EG, Egypt, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Dec 7, More...

MSC Cruises, MSC World Asia

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Dec 7, Dec 14, Dec 21, Dec 28, 2027: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, More...

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