Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Royal Caribbean, Explorer of the Seas

7 Night - Greek Isles Cruise
Starting in Ravenna, Italy, Santorini, Greece, Athens (Piraeus), Greece, Mykonos, Greece, Argostoli, Greece, Ravenna, Italy
2026 Sails: Jun 6, Aug 1, Aug 29, More...

Costa Cruise Lines, Costa Fascinosa

7 Night - Eastern Mediterranean from Taranto
Starting in Taranto, Argostoli / Cephalonia, Mykonos, Athens (Piraeus), Malta / La Valletta, Catania, Taranto
2026 Sails: Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, More...

Norwegian Cruise Line, Norwegian Gem

7 Night - Europe - Adriatic & Greece - Venice
Starting in Venice (Ravenna), Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Jun 7, Jul 19, Aug 30, Sep 13, Oct 11, Oct 25, More...

Uniworld Tours, S.S. La Venezia Tours

10 Night - Rome, Venice & the Jewels of Veneto
Starting in Venice, Venice (Padua), Mazzorbo (Burano), Mazzorbo, Burano, Chioggia, Chioggia, Chioggia, Venice, Venice, Venice, Transfer to Rome, Rome
2026 Sails: Jun 7, Jun 14, Jul 12, Jul 19, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 13, Sep 20, Sep 27, Oct 11, Nov 1, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Jun 8, Jun 29, Aug 10, More...

Cunard Line, Queen Victoria

7 Night - Central Mediterranean
Starting in Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Jun 8, More...

Cunard Line, Queen Victoria

14 Night - Adriatic and Western Mediterranean
Starting in Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: Jun 8, More...

Disney Cruise Line, Disney Dream

9 Night - Mediterranean with Greek Isles Cruise from Civitavecchia
Starting in Civitavecchia, Chania, Mykonos, Dubrovnik, Croatia, Corfu, Valletta, Civitavecchia
2026 Sails: Jun 8, More...

Explora Journeys, EXPLORA II

7 Night - A Journey to Adriatic Wonders & Whispered Ancient Secrets
Starting in Fusina (Venice), Rovinj, Zadar, Dubrovnik, Croatia, Brindisi, Milos, Piraeus (Athens)
2026 Sails: Jun 8, More...

Explora Journeys, EXPLORA II

14 Night - An Extended Journey Between Quiet Coasts & Luminous Isles
Starting in Fusina (Venice), Rovinj, Zadar, Dubrovnik, Croatia, Brindisi, Milos, Piraeus (Athens), Mykonos, Katapola, Pylos, Nydri, Lefkada, Bari, Piraeus (Athens)
2026 Sails: Jun 8, More...

<= Back

More =>