Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Istanbul, Turkey, Ephesus (Kusadasi), Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 25, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 25, Jul 6, Sep 28, More...

Virgin Voyages, Valiant Lady

6 Night - Amalfi Coast, Cannes & Ibiza
Starting in Civitavecchia (Rome), Italy, Amalfi Coast (Salerno), Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: May 25, More...

Princess Cruises, Enchanted Princess

14 Night - Mediterranean, Aegean & Adriatic
Starting in Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: May 26, Jun 9, Jul 7, Jul 21, Aug 18, Sep 1, More...

Norwegian Cruise Line, Norwegian Viva

9 Night - Greek Isles & Italy
Starting in Civitavecchia Rome, Italy, Amalfi Coast (Salerno), Italy, Catania, Italy, Valletta, Malta, Piraeus / Athens, Greece, Santorini Island, Greece, Izmir / Ephesus, Turkey, Istanbul, Turkey
2026 Sails: May 27, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Calanques national park bay, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Ibiza bay, Palermo (Sicily)
2026 Sails: May 28, Jun 18, Jul 2, More...

Celebrity Cruises, Celebrity Constellation

10 Night - Best of Italy & Croatia Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Sicily (Messina), Italy, Amalfi Coast (Salerno), Italy, Portofino, Italy, Florence / Pisa (Livorno), Italy, Rome (Civitavecchia), Italy
2026 Sails: May 29, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: May 29, Jun 19, Jul 3, Sep 25, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: May 29, Jun 7, Jun 16, Jun 25, Jul 4, Jul 13, Aug 9, Aug 27, Sep 5, Sep 14, Oct 2, Oct 11, Oct 20, Oct 29, Nov 7, More...

Silversea, Silver Ray

11 Night - Civitavecchia to Barcelona
Starting in Civitavecchia (Rome), Salerno, Livorno (Tuscany), Portofino, Porto Santo Stefano, Ajaccio (Corsica), Monte Carlo (Grand Prix), Barcelona
2026 Sails: May 29, More...

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