Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Norwegian Cruise Line, Norwegian Viva

10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Piraeus / Athens, Greece, Santorini Island, Greece, Rhodes, Greece, Kusadasi, Turkey, Thessaloniki, Greece, Istanbul, Turkey
2026 Sails: May 8, Jul 3, Aug 28, More...

Regent Seven Seas Cruises, Seven Seas Splendor

Deal link -> Special

7 Night - Ancient Sands
Starting in Rome (Civitavecchia), Naples / Pompeii, Valletta, Cruising the Mediterranean Sea, Katakolon, Santorini, Mykonos, Athens (Piraeus)
2026 Sails: May 8, More...

Silversea Cruises, Silver Spirit

7 Night - Civitavecchia to Lisbon
Starting in Civitavecchia (Rome), Livorno (Tuscany), Valencia, Cartagena ES, Spain, Portimao, Lisbon
2026 Sails: May 8, More...

Silversea Cruises, Silver Spirit

19 Night - Mediterranean from Rome (Civitavecchia) to Southampton
Starting in Civitavecchia, Livorno, Valencia, Cartagena ES, Portimao, Lisbon, Vigo, Santander, Bilbao, Bordeaux, Saint Malo, St Peter Port, Southampton
2026 Sails: May 8, More...

AmaWaterways Cruise Tours, AmaSerena Cruise Tours

10 Night - Swiss Alps & Rhine Castles with Lake Como Pre-Cruise
Starting in Lake Como, Lucerne, Basel, Strasbourg, Ludwigshafen, Rudesheim, Rhine Gorge, Lahnstein, Cologne, Amsterdam
2026 Sails: May 9, May 23, Jun 6, Jun 20, Jul 4, Jul 18, Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Kotor, Montenegro, Corfu, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: May 9, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy
2026 Sails: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 5, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Bari, Italy, Santorini, Greece, Piraeus (Athens), Greece, Katakolon (Olympia), Greece, Cefalonia / Argostoli, Greece, Corfu, Greece, Bari, Italy
2026 Sails: May 9, More...

Viking Ocean, Viking Saturn

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2026 Sails: May 9, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy
2026 Sails: May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, More...

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