Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC World Europa

21 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, La Spezia (Cinque Terre), Italy, Marseille (Provence), France, Barcelona, Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de Tenerife, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, Kingstown, St Vincent and the Grenadines, Bridgetown, Barbados, Saint George, Grenada, Fort-de-France, Martinique
2026 Sails: Nov 14, More...

MSC Cruises, MSC World Europa

3 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, La Spezia (Cinque Terre), Italy, Marseille (Provence), France
2026 Sails: Nov 14, More...

MSC Cruises, MSC World Europa

28 Night - Msc Grand Voyages
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, La Spezia (Cinque Terre), Italy, Marseille (Provence), France, Barcelona, Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de Tenerife, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, Kingstown, St Vincent and the Grenadines, Bridgetown, Barbados, Saint George, Grenada, Fort-de-France, Martinique, Pointe-A-Pitre, Guadeloupe, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, Roseau, Dominica, Fort-de-France, Martinique
2026 Sails: Nov 14, More...

Costa Cruise Lines, Costa Deliziosa

6 Night - Eastern Mediterranean from Bari
Starting in Bari, Corfu, Siracusa, Malta / La Valletta, Trieste, Bari
2026 Sails: Nov 15, More...

Costa Cruise Lines, Costa Fascinosa

10 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Gibraltar, Lisbon, Cadiz, Malaga, Marseille, Savona
2026 Sails: Nov 15, More...

Explora Journeys, EXPLORA II

4 Night - A Journey Through Ionian Beauty and Santorini Skies
Starting in Bari, Sarande, Santorini, Piraeus (Athens)
2026 Sails: Nov 15, More...

MSC Cruises, MSC World Europa

20 Night - Msc Grand Voyages
Starting in Civitavecchia (Rome), Italy, La Spezia (Cinque Terre), Italy, Marseille (Provence), France, Barcelona, Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de Tenerife, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, Kingstown, St Vincent and the Grenadines, Bridgetown, Barbados, Saint George, Grenada, Fort-de-France, Martinique
2026 Sails: Nov 15, More...

Oceania Cruises, Oceania Marina

25 Night - Europe to the Caribbean
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Mahon (Menorca), Palma De Mallorca, Barcelona, Valencia, Alicante, Malaga, Funchal (Madeira), San Juan, Puerto Plata, Dominican Republic, Miami
2026 Sails: Nov 15, More...

Princess Cruises, Enchanted Princess

16 Night - Moroccan Passage
Starting in Civitavecchia (for Rome), Italy, Mallorca (Palma), Spain, Gibraltar, Casablanca, Morocco (for Marrakesh), Santa Cruz de Tenerife, La Palma, Canary Islands, Spain, Fort Lauderdale, Florida
2026 Sails: Nov 17, More...

Viking Ocean, Viking Mira

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Nov 18, Dec 16, More...

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