Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Norwegian Cruise Tours, Norwegian Viva Cruise Tours

13 Night - Pre Venice Cruisetour
Starting in At Hotel, Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Piraeus / Athens, Greece, Santorini Island, Greece, Rhodes, Greece, Kusadasi, Turkey, Thessaloniki, Greece, Istanbul, Turkey
2026 Sails: May 5, Jun 30, Aug 25, More...

Seabourn, Seabourn Venture

9 Night - Tyrrhenian Yacht Treasures
Starting in Civitavecchia (Rome), Italy, Amalfi, Italy, Lipari, Italy, Giardini Naxos (Taormina), Italy, Palermo, Sicily, Italy, Cagliari, Sardinia, Italy, Bonifacio (Corsica), France, Calvi, Corsica, France, Mahon, Menorca, Spain, Barcelona, Spain
2026 Sails: May 5, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 6, May 13, May 20, May 27, Jun 3, Jun 10, Jun 17, Jun 24, Jul 1, Jul 8, Jul 15, Jul 22, Jul 29, Aug 5, Aug 12, Aug 19, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy
2026 Sails: May 6, May 13, May 20, May 27, Jun 10, Jun 17, Jun 24, Jul 1, Jul 8, Jul 15, Jul 22, Jul 29, Aug 5, Aug 12, Aug 19, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, Oct 21, More...

Ritz-Carlton Yacht Collection, Evrima

7 Night - Rome (Civitavecchia) / Monte Carlo
Starting in Rome (Civitavecchia), Portoferraio, Elba, Bastia, Corsica, Livorno, Portofino, Cannes, Monte Carlo
2026 Sails: May 6, More...

Silversea Cruises, Silver Muse

11 Night - Fusina to Civitavecchia
Starting in Fusina (Venice), Zadar, Hvar, Dubrovnik, Croatia, Bari, Kotor, Valletta, Giardini Naxos (Sicily), Palermo, Sicily, Naples, Civitavecchia (Rome)
2026 Sails: May 6, More...

Viking Ocean, Viking Jupiter

7 Night - Italian Sojourn
Starting in Venice, Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia)
2026 Sails: May 6, 2027: May 12, Aug 28, More...

Viking Ocean, Viking Jupiter

14 Night - Mediterranean & Italian Sojourn
Starting in Venice, Sibenik, Bari, Crotone, Sicily (Messina), Naples, Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: May 6, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Savona
Starting in Savona, Barcelona, Marseille, Savona
2026 Sails: May 7, Oct 22, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy
2026 Sails: May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, More...

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