Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Silversea, Silver Muse

9 Night - Fusina to Fusina
Starting in Fusina (Venice), Trieste, Rovinj, Kotor, Bari, Dubrovnik, Croatia, Hvar, Zadar, Fusina (Venice)
2026 Sails: May 22, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera, Bari, Corfu, Zakynthos, Argostoli / Cephalonia, Dubrovnik, Croatia, Split, Croatia, Marghera
2026 Sails: May 23, Jun 20, Jul 4, Aug 1, Aug 15, Sep 12, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Turkey, & Adriatic
Starting in Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Crete (Heraklion), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 23, More...

Royal Caribbean, Explorer of the Seas

7 Night - Greece & Croatia Cruise
Starting in Ravenna, Italy, Dubrovnik, Croatia, Athens (Piraeus), Greece, Santorini, Greece, Zadar, Croatia, Ravenna, Italy
2026 Sails: May 23, Aug 15, More...

Star Clippers, Star Clipper

18 Night - Grand Voyage : Rome to Venice
Starting in Civitavecchia (Port for Rome), Italy, Lipari / Aeolian Islands, Italy, Stromboli, Italy (Sailing in Area), Messina, Sicily, Italy, Amalfi, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Ponza / Pontine Islands, Italy, Amalfi, Italy, Lipari / Aeolian Islands, Italy, Taormina, Sicily, Italy, Crotone, Italy, Otranto, Italy, Monopoli, Italy, Barletta, Italy, Rovinj, Croatia, Venice, Italy
2026 Sails: May 23, More...

Holland America, Oosterdam

10 Night - Western Mediterranean : Idyllic Isles & Hidden Gems
Starting in Civitavecchia (Rome), Italy, Salerno, Italy, Palermo, Sicily, Italy, Cagliari, Sardinia, Italy, Palma De Mallorca, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Lisbon, Portugal
2026 Sails: May 24, More...

Holland America, Oosterdam

21 Night - Italy, Spain & Malta Collectors Voyage
Starting in Civitavecchia (Rome), Italy, Salerno, Italy, Palermo, Sicily, Italy, Cagliari, Sardinia, Italy, Palma De Mallorca, Spain, Alicante, Spain, Gibraltar, Cadiz (Seville), Spain, Lisbon, Portugal, Cadiz (Seville), Spain, Tangier, Morocco, Valencia, Spain, Valletta, Malta, Cruising Strait of Messina, Passing Isola di Stromboli, Salerno, Italy, Civitavecchia (Rome), Italy
2026 Sails: May 24, More...

MSC Cruises, MSC Armonia

7 Night - Mediterranean
Starting in Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy
2026 Sails: May 24, More...

Norwegian Cruise Line, Norwegian Gem

7 Night - Europe - Adriatic & Greece - Venice
Starting in Venice (Ravenna), Italy, Koper, Slovenia, Split, Croatia, Kotor, Montenegro, Corfu, Greece, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: May 24, More...

Regent Seven Seas, Seven Seas Grandeur

13 Night - Spotlight On Faberge
Starting in Rome (Civitavecchia), Tuscany (Livorno), Monte Carlo, Barcelona, Cruising the Mediterranean Sea, Cruising the Atlantic Ocean, La Coruna, Cruising the English Channel, Paris (Honfleur), London (Southampton)
2026 Sails: May 24, More...

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