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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Ravenna : Rome : Savona : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Costa Cruise Lines, Costa Fortuna
Costa Fortuna Cruise Ship5 Night - Mediterranean from Rome (Civitavecchia) to Athens (Piraeus)
Starting in Civitavecchia, Messina, Malta / La Valletta, Heraklion, Athens (Piraeus)
2026 Sails: May 3, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna Cruise Ship12 Night - Mediterranean from Rome (Civitavecchia) to Athens (Piraeus)
Starting in Civitavecchia, Messina, Malta / La Valletta, Heraklion, Athens (Piraeus), Volos, Istanbul, Izmir, Mykonos, Santorini, Athens (Piraeus)
2026 Sails: May 3, More...
MSC Cruises, MSC Fantasia
MSC Fantasia Cruise Ship9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Izmir (Ephesus), Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: May 3, May 21, Jul 23, More...
MSC Cruises, MSC Opera
MSC Opera Cruise Ship1 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France
2026 Sails: May 3, More...
MSC Cruises, MSC Opera
MSC Opera Cruise Ship3 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: May 3, More...
MSC Cruises, MSC Opera
MSC Opera Cruise Ship5 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Gibraltar, Lisbon (Cascais), Portugal
2026 Sails: May 3, More...
MSC Cruises, MSC Opera
MSC Opera Cruise Ship10 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Gibraltar, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy
2026 Sails: May 3, More...
MSC Cruises, MSC Seaview
MSC Seaview Cruises7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, More...
Norwegian Cruise Line (NCL), NCL Norwegian Pearl
NCL Norwegian Pearl Cruise Ship7 Night - Europe - Greek Isles - Venice
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Corfu, Greece, Olympia / Katakolon, Greece, Mykonos, Greece, Santorini Island, Greece, Piraeus / Athens, Greece
2026 Sails: May 3, May 31, Jun 28, Jul 26, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, Oct 18, More...
Royal Caribbean International (RCL), RCL Odyssey of the Seas
RCL Odyssey of the Seas Cruises7 Night - Greek Isles Cruise
Starting in Rome (Civitavecchia), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: May 3, May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, More...

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Italy Cruise Departures