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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Cagliari, Palermo, Civitavecchia (Rome), Savona
2026 Sails: Nov 8, More...
MSC Cruises, MSC Magnifica
MSC Magnifica7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 8, Nov 15, Nov 22, Nov 29, More...
MSC Cruises, MSC Magnifica
MSC Magnifica5 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Nov 8, More...
MSC Cruises, MSC Seaview
MSC Seaview6 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 8, More...
MSC Cruises, MSC World Europa
MSC World Europa6 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 8, More...
Regent Seven Seas, Seven Seas Grandeur
Seven Seas Grandeur14 Night - New World Passage
Starting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami
2026 Sails: Nov 8, More...
MSC Cruises, MSC Magnifica
MSC Magnifica7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Nov 9, Nov 16, Nov 23, More...
MSC Cruises, MSC Seaview
MSC Seaview5 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 9, More...
MSC Cruises, MSC World Europa
MSC World Europa6 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy
2026 Sails: Nov 9, More...
MSC Cruises, MSC World Europa
MSC World Europa5 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 9, More...

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Italy Cruise Departures