Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Deliziosa

14 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice), Bari, Corfu, Argostoli (Cephalonia), Dubrovnik, Croatia, Kotor, Zadar, Marghera (Venice)
2026 Sails: Aug 29, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Thira (Santorini), Mykonos, Katakolon (Olympia), Marghera (Venice)
2026 Sails: Aug 29, More...

Costa Cruise Lines, Costa Pacifica

3 Night - Southern Europe from Rome (Civitavecchia) to Palma De Mallorca
Starting in Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Aug 29, More...

Holland America, Oosterdam

7 Night - Western Mediterranean
Starting in Civitavecchia (Rome), Italy, Portofino, Italy, Ajaccio, Corsica, France, Marseille (Provence), France, Gibraltar, Barcelona, Spain
2026 Sails: Aug 29, 2027: Jul 10, More...

SeaDream Yacht Club, SeaDream I

7 Night - Sorrentine Peninsula Sojourn Cruise
Starting in Rome (Civitavecchia), Bonifacio, Corsica, Ponza, Amalfi, Positano, Sorrento, Capri, Rome (Civitavecchia)
2026 Sails: Aug 29, More...

Star Clippers, Royal Clipper

14 Night - Grand Voyage : Venice to Rome
Starting in Venice, Italy, Rovinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Monopoli, Italy, Syracuse IT, Sicily, Italy, Lipari / Aeolian Islands, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Palmarola / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy, Saint-Florent / Corsica, France, Portoferraio / Elba, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Aug 29, More...

Star Clippers, Royal Clipper

11 Night - Italy, Montenegro, Croatia
Starting in Venice, Italy, Rovinj, Croatia, Sibenik, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Monopoli, Italy, Syracuse IT, Sicily, Italy, Lipari / Aeolian Islands, Italy, Sorrento, Italy, Ponza / Pontine Islands, Italy, Palmarola / Pontine Islands, Italy, Civitavecchia (Port for Rome), Italy
2026 Sails: Aug 29, More...

Crystal Cruises, Crystal Serenity

23 Night - Europe & Mediterranean
Starting in Civitavecchia (Rome), Sorrento, Siracusa (Sicily), Corfu, Kotor, Zadar, Ravenna, Fusina (Venice), Trieste, Dubrovnik, Croatia, Corfu, Argostoli (Cephalonia), Monemvasia (Laconia), Athens (Piraeus), Santorini, Bodrum, Valletta, Trapani, Cagliari (Sardinia), Civitavecchia (Rome)
2026 Sails: Aug 30, More...

Crystal Cruises, Crystal Serenity

9 Night - Europe & Mediterranean
Starting in Civitavecchia (Rome), Sorrento, Siracusa (Sicily), Corfu, Kotor, Zadar, Ravenna, Fusina (Venice)
2026 Sails: Aug 30, More...

Celebrity Cruises, Celebrity Constellation

11 Night - Best of Italy & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Amalfi Coast (Salerno), Italy, Sicily (Messina), Italy, Kotor, Montenegro, Dubrovnik, Croatia, Split, Croatia, Zadar, Croatia, Ravenna, Italy
2026 Sails: Aug 31, More...

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