Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Uniworld Tours, S.S. La Venezia Tours

16 Night - Cruise & Rail : Venice, Istanbul & the Balkans
Starting in Venice, Venice (Padua), Mazzorbo (Burano), Mazzorbo, Burano, Chioggia, Chioggia, Chioggia, Venice, Venice, Venice, Transfer to Train, Trieste, Postojna, Pula, Rijeka, Sarajevo, Mostar, Belgrade, Sofia, Plovdiv, Istanbul
2026 Sails: Aug 23, Sep 27, 2027: May 2, More...

Cunard Line, Queen Victoria

Deal link -> Special

7 Night - Italy and Adriatic
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Aug 24, More...

Cunard Line, Queen Victoria

14 Night - Italy, Spain and Adriatic
Starting in Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Aug 24, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Italian Riviera & France
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Aug 25, More...

Princess Cruises, Enchanted Princess

14 Night - Mediterranean, Aegean & Adriatic
Starting in Civitavecchia (for Rome), Italy, Corfu, Greece, Dubrovnik, Croatia, Kotor, Montenegro, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Santorini, Greece, Kusadasi, Turkey (for Ephesus), Katakolon (for Olympia), Greece, Civitavecchia (for Rome), Italy
2026 Sails: Aug 25, Oct 6, More...

Windstar, Wind Surf

15 Night - Star Collector : Iconic Italy and Croatia
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice
2026 Sails: Aug 26, More...

Windstar, Wind Surf

7 Night - Jewels of the Italian and French Rivieras
Starting in Rome, Bastia, Cannes, Monte Carlo, Genoa, Italy, Portofino, Porto Ercole, Rome
2026 Sails: Aug 26, More...

Royal Caribbean, Legend of the Seas

7 Night - Western Mediterranean Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, More...

Celebrity Cruises, Celebrity Ascent

10 Night - Italy, Greece & Croatia Cruise
Starting in Rome (Civitavecchia), Italy, Sicily (Messina), Italy, Olympia (Katakolon), Greece, Corfu, Greece, Montenegro, Split, Croatia, Dubrovnik, Croatia, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Aug 28, More...

Norwegian Cruise Line, Norwegian Viva

10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Montenegro, Piraeus / Athens, Greece, Santorini Island, Greece, Rhodes, Greece, Kusadasi, Turkey, Thessaloniki, Greece, Istanbul, Turkey
2026 Sails: Aug 28, More...

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