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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

Avalon Waterways Tours, Avalon Envision Tours
Avalon Envision Tours18 Night - Timeless Rivers of Europe : the Rhine and Seine with Swiss Alps, in Lake Como & in Lucerne
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation) Paris, France (Embarkation), Vernon, Caudebec, Caudebec Excursion to Normandy, Rouen, Conflans, Paris, Paris (Disembarkation)
2026 Sails: Nov 6, More...
Avalon Waterways Tours, Avalon Envision Tours
Avalon Envision Tours11 Night - Romantic Rhine with Swiss Alps, in Lake Como & in Lucerne (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: Nov 6, Dec 4, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda5 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Civitavecchia (Rome)
2026 Sails: Nov 6, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Nov 6, Nov 13, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana3 Night - Western Mediterranean from Genova (Portofino)
Starting in Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca
2026 Sails: Nov 6, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Cagliari, Palermo, Civitavecchia (Rome)
2026 Sails: Nov 7, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, Civitavecchia (Rome), Savona
2026 Sails: Nov 7, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 7, More...
Oceania Cruises, Oceania Allura
Oceania Allura10 Night - Artists & Aristocrats
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Trapani (Sicily), Tunis (La Goulette), Cagliari (Sardinia), Cartagena ES, Valencia, Barcelona
2026 Sails: Nov 7, More...
Viking Ocean, Viking Saturn
Viking Saturn7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Nov 7, 2027: Jan 3, Feb 15, Dec 30, More...

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Italy Cruise Departures