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Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Naples : Napoli : Olbia : Palermo : Ravenna : Rome : Savona : Syracuse : Taranto : Trieste : Venice

Departing from
Italy
Cruise Specials

MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy
2026 Sails: Feb 18, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, Apr 8, Apr 15, More...
MSC Cruises, MSC Splendida
MSC Splendida7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy
2026 Sails: Feb 18, Feb 25, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, Apr 8, Apr 15, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Italy, Savona, Italy, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, La Goulette, Tunisia, Tunis Gulf, Palermo (Sicily)
2026 Sails: Feb 19, Feb 26, Mar 5, More...
MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Feb 19, Feb 26, Mar 5, Mar 12, Mar 19, Mar 26, Apr 2, Apr 9, Apr 16, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia, Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia
2026 Sails: Feb 20, Feb 27, Mar 6, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda2 Night - Southern Europe from Rome (Civitavecchia) to Marseille
Starting in Civitavecchia, Savona, Marseille
2026 Sails: Feb 20, Feb 27, More...
Windstar, Star Legend
Star Legend16 Night - Star Collector : Winter in Spain and the Rivieras
Starting in Rome, Livorno, Genoa, Italy, Nice, Barcelona, Valencia, Cartagena ES, Gibraltar, Malaga, Palma De Mallorca, Barcelona
2026 Sails: Feb 20, More...
Windstar, Star Legend
Star Legend7 Night - Europe's Winter Riviera
Starting in Rome, Livorno, Genoa, Italy, Nice, Barcelona
2026 Sails: Feb 20, 2027: Nov 5, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Feb 21, Feb 28, Mar 7, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda5 Night - Western Mediterranean from Savona
Starting in Savona, Marseille, Barcelona, La Goulette, Palermo
2026 Sails: Feb 21, More...

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Italy Cruise Departures