Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Carnival Cruise Lines, Carnival Legend

9 Night - Croatia Greece & Italy
Starting in Civitavecchia (Rome), Italy, Split, Croatia, Kotor, Montenegro, Dubrovnik, Croatia, Corfu, Greece, Naples (Amalfi / Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 2, More...

Celebrity Cruises, Celebrity Constellation

10 Night - Best of Italy & Croatia Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Sicily (Messina), Italy, Amalfi Coast (Salerno), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Oct 2, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: Oct 2, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Oct 2, Oct 9, More...

MSC Cruises, MSC Divina

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Oct 2, Oct 9, Oct 16, Oct 23, 2027: Jun 25, Jul 23, Jul 30, Aug 20, Sep 3, Sep 17, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Oct 2, Oct 11, Oct 20, Oct 29, Nov 7, More...

MSC Cruises, MSC Lirica

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: Oct 2, Oct 9, Oct 16, 2027: Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: Oct 2, Oct 9, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Trieste
Starting in Trieste, Bari, Corfu, Siracusa, Malta / La Valletta, Split, Trieste
2026 Sails: Oct 3, Oct 17, Oct 31, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, La Goulette (Tunis), Palermo, Civitavecchia (Rome)
2026 Sails: Oct 3, Oct 10, Oct 17, Oct 24, Oct 31, Nov 14, More...

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