Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Savona, Marseille, Barcelona, Ibiza, Palermo, Civitavecchia (Rome)
2026 Sails: Jul 3, Sep 25, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Genova
Starting in Genoa (Portofino), Marseille, Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino)
2026 Sails: Jul 3, Jul 10, Jul 17, More...

MSC Cruises, MSC Armonia

Deal link -> Special

7 Night - Mediterranean
Starting in Brindisi (Lecce), Italy, Split, Croatia, Venice / Marghera, Italy, Dubrovnik, Croatia, Corfu, Greece, Kotor, Montenegro, Brindisi (Lecce), Italy
2026 Sails: Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, 2027: Apr 30, May 7, May 14, May 21, Jun 4, Jun 11, Jun 25, More...

MSC Cruises, MSC Divina

Deal link -> Special

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Mykonos, Greece, Kusadasi, Turkey, Marmaris, Turkey, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, 2027: Jun 25, Jul 23, Jul 30, Aug 20, Sep 3, Sep 17, More...

MSC Cruises, MSC Lirica

Deal link -> Special

7 Night - Mediterranean
Starting in Ancona (Urbino), Italy, Venice / Marghera, Italy, Kotor, Montenegro, Mykonos, Greece, Syros, Greece, Ancona (Urbino), Italy
2026 Sails: Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, 2027: Apr 16, Apr 23, Apr 30, May 7, May 14, May 21, May 28, Jun 4, More...

MSC Cruises, MSC Meraviglia

Deal link -> Special

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy
2026 Sails: Jul 3, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, More...

Norwegian Cruise Line, Norwegian Viva

10 Night - Greek Isles & Italy
Starting in Venice (Ravenna), Italy, Dubrovnik, Croatia, Montenegro, Piraeus / Athens, Greece, Kusadasi, Turkey, Rhodes, Greece, Santorini Island, Greece, Istanbul, Turkey
2026 Sails: Jul 3, More...

Silversea, Silver Muse

9 Night - Fusina to Fusina
Starting in Fusina (Venice), Trieste, Rovinj, Kotor, Bari, Dubrovnik, Croatia, Hvar, Zadar, Fusina (Venice)
2026 Sails: Jul 3, More...

Costa Cruise Lines, Costa Deliziosa

7 Night - Eastern Mediterranean from Marghera
Starting in Marghera (Venice), Bari, Corfu, Zakynthos, Argostoli (Cephalonia), Dubrovnik, Croatia, Split, Marghera (Venice)
2026 Sails: Jul 4, Aug 1, Aug 15, More...

Costa Cruise Lines, Costa Fascinosa

7 Night - Eastern Mediterranean from Catania
Starting in Catania, Taranto, Argostoli (Cephalonia), Mykonos, Piraeus (Athens), Malta / La Valletta, Catania
2026 Sails: Jul 4, Jul 18, Aug 1, Aug 8, Aug 15, Aug 29, More...

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