Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 16, Nov 23, Nov 30, Dec 7, Dec 14, Dec 21, Dec 28, 2027: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, More...

MSC Cruises, MSC Magnifica

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Nov 16, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy
2026 Sails: Nov 17, Dec 1, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Livorno (Florence), Italy, Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy
2026 Sails: Nov 17, More...

Princess Cruises, Enchanted Princess

16 Night - Moroccan Passage
Starting in Civitavecchia (for Rome), Italy, Mallorca (Palma), Spain, Gibraltar, Casablanca, Morocco (for Marrakesh), Santa Cruz de Tenerife, La Palma, Canary Islands, Spain, Fort Lauderdale, Florida
2026 Sails: Nov 17, More...

MSC Cruises, MSC Euribia

7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy
2026 Sails: Nov 18, Nov 25, Dec 2, Dec 9, Dec 16, Dec 23, Dec 30, 2027: Jan 6, Jan 13, Jan 20, Jan 27, Feb 3, Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, More...

Viking Ocean, Viking Mira

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Nov 18, Dec 16, More...

Viking Ocean, Viking Vesta

7 Night - Italian Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Nov 18, More...

Costa Cruise Lines, Costa Toscana

8 Night - Western Mediterranean from Civitavecchia
Starting in Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca, Alicante, Palermo, Civitavecchia (Rome)
2026 Sails: Nov 19, More...

Costa Cruise Lines, Costa Deliziosa

5 Night - Western Mediterranean from Trieste
Starting in Trieste, Bari, Corfu, Civitavecchia (Rome), Savona
2026 Sails: Nov 20, More...

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