Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Livorno : Marghera : Messina : Milan : Naples : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Celebrity Cruises, Celebrity Ascent

Deal link -> Special

11 Night - Greece, Turkey & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Chania (Souda), Crete, Greece, Ephesus (Kusadasi), Turkey, Istanbul, Turkey, Santorini, Greece, Mykonos, Greece, Naples, Italy, Rome (Civitavecchia), Italy
2026 Sails: Oct 19, 2027: May 24, Aug 16, Sep 27, More...

Royal Caribbean, Brilliance of the Seas

7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Catania, Sicily, Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
More...

Sea Cloud, Sea Cloud II

8 Night - On the Trail of the Old Venetians
Starting in Venice, Komiza / Vis Island, Hvar, Korcula, Trogir, Sibenik, Rovinj, Venice
More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Aug 18, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Livorno (Florence), Italy, Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy
2026 Sails: Aug 18, Aug 25, Sep 8, Oct 20, Oct 27, Nov 3, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy
2026 Sails: Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, Oct 27, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Trieste (Venice), Italy, Katakolon (Olympia), Greece, Santorini, Greece, Piraeus (Athens), Greece, Istanbul, Turkey, Corfu, Greece, Bari, Italy, Trieste (Venice), Italy
2026 Sails: Aug 19, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy
2026 Sails: Aug 19, Aug 26, Sep 2, Sep 9, Sep 16, Sep 23, Sep 30, Oct 7, Oct 14, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Cagliari (Sardinia), Italy, Palermo (Monreale), Italy, La Valletta, Malta, Barcelona, Spain, Marseille (Provence), France, Livorno (Florence), Italy, Cagliari (Sardinia), Italy
2026 Sails: Aug 19, Sep 9, Sep 16, Sep 23, Sep 30, Oct 14, Oct 28, Nov 4, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Calanques national park bay, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Ibiza bay, Palermo (Sicily)
2026 Sails: Aug 20, Aug 27, Sep 3, More...

More =>