Italy Cruise Departures

Cruises that depart from Mediterranean: Italy

Cruises that visit Italy

See all River Cruises that depart from Italy

Click on a cruise ship itinerary sailing from Italy (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Italy), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Ancona : Bari : Brindisi : Cagliari : Catania : Cernobbio : Civitavecchia : Fusina : Genoa : La Spezia : Lake Como : Lecce : Livorno : Marghera : Messina : Milan : Naples : Napoli : Olbia : Palermo : Perugia : Ravenna : Rome : Savona : Taormina : Taranto : Trieste : Venice

Royal Caribbean, Brilliance of the Seas

7 Night - Italy, Spain & French Riviera
Starting in Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Santa Margherita, Italy, Nice (Villefranche), France, Provence (Marseille), France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jun 15, More...

MSC Cruises, MSC Fantasia

9 Night - Mediterranean
Starting in Bari, Italy, Trieste (Venice), Italy, Katakolon (Olympia), Greece, Piraeus (Athens), Greece, Kusadasi, Turkey, Istanbul, Turkey, Corfu, Greece, Bari, Italy
2026 Sails: Jun 16, Jul 4, More...

Princess Cruises, Enchanted Princess

7 Night - Mediterranean & Adriatic
Starting in Civitavecchia (for Rome), Italy, Amalfi Coast (Salerno), Kotor, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Civitavecchia (for Rome), Italy
2026 Sails: Jun 16, More...

Regent Seven Seas, Seven Seas Voyager

12 Night - Treasures of the Adriatic
Starting in Venice (Trieste), Cruising the Adriatic Sea, Dubrovnik, Croatia, Cruising the Ionian Sea, Heraklion (Crete), Athens (Piraeus), Cruising the Aegean Sea, Istanbul
2026 Sails: Jun 16, More...

Viking Ocean, Viking Sea

7 Night - Venice, the Adriatic & Greece
Starting in Venice (Chioggia), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Jun 16, More...

Disney Cruise Line, Disney Dream

7 Night - Mediterranean with Greek Isles Cruise from Civitavecchia
Starting in Civitavecchia, Santorini, Mykonos, Chania, Naples, Civitavecchia
2026 Sails: Jun 17, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean Roundtrip from Palermo
Starting in Palermo (Sicily), Civitavecchia / Rome, Savona, Italy, Calanques national park bay, Marseille, France, Barcelona, Spain, Balearic sea darkest spot, Ibiza, Spain, Ibiza bay, Palermo (Sicily)
2026 Sails: Jun 18, Jul 2, More...

PONANT, Le Boreal

7 Night - Cruising the Dalmatian Coast and the Ionian Sea : Venice to Athens - with Smithsonian Journeys
Starting in Venice, Hvar, Ploce, Dubrovnik, Croatia, Kotor, Sarande, Katakolon, Athens
2026 Sails: Jun 18, More...

Avalon Waterways Tours, Avalon Envision Tours

11 Night - Romantic Rhine with Swiss Alps, in Lake Como & in Lucerne (Northbound)
Starting in Lake Como, Italy, Lake Como, Lake Como / Lucerne, Switzerland, Lucerne / Swiss Alps / Basel (Embarkation), Breisach, Germany Excursion to Black Forest, Kehl Excursion to Strasbourg, France, Mainz, Germany Excursion to Heidelberg, Rudesheim / Rhine Gorge, Cologne, Amsterdam, Holland, Amsterdam (Disembarkation)
2026 Sails: Jun 19, Jul 3, Jul 17, Jul 31, Aug 28, Sep 11, Oct 9, Oct 23, Nov 6, Nov 20, Dec 4, More...

Celebrity Cruises, Celebrity Constellation

10 Night - Best of Italy & Croatia Cruise
Starting in Ravenna, Italy, Split, Croatia, Dubrovnik, Croatia, Kotor, Montenegro, Sicily (Messina), Italy, Amalfi Coast (Salerno), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy
2026 Sails: Jun 19, Jul 10, Jul 31, More...

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