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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Alabama : Florida : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Washington : Washington DC : Wyoming


American Serenade7 Night - Highlights of the Mississippi Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2027 Sails: Feb 13, Oct 28, Nov 3, More...
American Splendor8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2027 Sails: Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, Apr 27, May 11, May 25, Jun 8, Jun 22, Jul 6, Oct 12, Oct 26, Nov 9, 2028: Feb 15, Feb 29, Mar 14, Mar 28, Apr 11, Apr 25, May 9, May 23, Jun 6, Jun 20, More...
American Serenade8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2027 Sails: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, Nov 9, Nov 23, Dec 7, Dec 21, 2028: Feb 18, Mar 3, Mar 17, Mar 31, Apr 28, May 12, May 26, Sep 8, Nov 26, Dec 10, Dec 24, More...
American Splendor8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2027 Sails: Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Oct 5, Oct 19, Nov 2, 2028: Feb 22, Mar 7, Mar 21, Apr 4, Apr 18, May 2, May 16, May 30, Jun 13, Jun 27, Oct 31, More...
American Serenade8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2027 Sails: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, Jun 4, Nov 16, Nov 30, Dec 14, Dec 28, 2028: Feb 11, Feb 25, Mar 10, Mar 24, Apr 21, May 5, May 20, Jun 2, Sep 15, Oct 2, Oct 20, Nov 19, Dec 3, More...
American Eagle8 Night - Southeast Sea Islands Cruise
Starting in Amelia Island, FL, Day of Cruising, Jekyll Island / St Simons Island, GA, Cruising Intracoastal Waterway, Savannah, GA, Hilton Head Island, SC, Beaufort, SC, Charleston, SC
2027 Sails: Mar 19, Apr 2, Apr 16, Apr 30, Nov 8, 2028: Feb 4, Feb 18, Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, Nov 13, More...
American Pride6 Night - Columbia River Gorge Cruise
Starting in Portland-OR, Cruising the Columbia River, Hood River, OR, The Dalles, OR, Day of Cruising the Columbia River Gorge, Kalama, WA, Portland-OR
2027 Sails: Mar 22, Mar 27, Apr 1, Apr 6, Oct 24, Oct 29, Nov 3, More...
American Legend15 Night - East Coast Inland Passage Cruise
Starting in Amelia Island, FL, Day of Cruising, Jekyll Island, GA, St Simons Island, GA, Savannah, GA, Hilton Head, SC, Beaufort, SC, Charleston, SC, Day of Cruising, Wilmington, NC, Beaufort, NC / Morehead City, NC, Kitty Hawk, NC, Norfolk, Va, St Michaels, MD, Washington, DC
2027 Sails: Mar 24, 2028: Mar 8, More...
American Encore8 Night - Columbia & Snake Rivers Cruise
Starting in Portland-OR, Cruising the Columbia River, Astoria, Or, Kalama, WA, The Dalles, OR, Cruising the Columbia River, Pendleton, OR / Richland, WA, Clarkston, WA
2027 Sails: Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, Oct 22, Nov 5, 2028: Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jun 16, More...
American Song8 Night - Columbia & Snake Rivers Cruise
Starting in Portland-OR, Cruising the Columbia River, Astoria, Or, Kalama, WA, The Dalles, OR, Cruising the Columbia River, Pendleton, OR / Richland, WA, Clarkston, WA
2027 Sails: Mar 30, Apr 13, Apr 27, May 11, May 25, Jun 8, Jun 22, Jul 6, Jul 20, Aug 3, Aug 17, Aug 31, Sep 14, Sep 28, Oct 12, Oct 26, Nov 9, 2028: Mar 28, Apr 11, Apr 25, May 9, May 23, Jun 6, Jun 20, More...


United States River Cruise Departures