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Pennsylvania River Cruise Departures

River Cruises that depart from North America: United States: Pennsylvania

River Cruises that visit Pennsylvania

See all Cruises that depart from Pennsylvania

Click on a cruise ship itinerary sailing from Pennsylvania (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pennsylvania), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Philadelphia : Pittsburgh


American Cruise Lines, American Melody
American Melody8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, More...
American Cruise Lines, American Heritage
American Heritage8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, More...
American Cruise Lines, American Melody
American Melody15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
American Cruise Lines, American Heritage
American Heritage15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
American Cruise Lines, American Legend
American Legend11 Night - American Revolution Cruise
Starting in Philadelphia, Pa, Day of Cruising, Annapolis, MD, St Michaels, MD, Day of Cruising, Norfolk, Va, Yorktown / Jamestown, VA, Williamsburg, VA, Mount Vernon, VA, Washington, DC
2027 Sails: Apr 17, May 7, 2028: Nov 1, More...
American Cruise Lines, American Liberty
American Liberty11 Night - American Revolution Cruise
Starting in Philadelphia, Pa, Day of Cruising, Annapolis, MD, St Michaels, MD, Day of Cruising, Norfolk, Va, Yorktown / Jamestown, VA, Williamsburg, VA, Mount Vernon, VA, Washington, DC
2027 Sails: Jul 12, More...
American Cruise Lines, American Symphony
American Symphony8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2027 Sails: Jul 26, Aug 11, 2028: Jul 24, Aug 9, Aug 25, Sep 10, More...
American Cruise Lines, American Symphony
American Symphony15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2027 Sails: Aug 27, 2028: Sep 26, More...
American Cruise Lines, American Mariner
American Mariner11 Night - American Revolution Cruise
Starting in Philadelphia, Pa, Day of Cruising, Annapolis, MD, St Michaels, MD, Day of Cruising, Norfolk, Va, Yorktown / Jamestown, VA, Williamsburg, VA, Mount Vernon, VA, Washington, DC
2027 Sails: Dec 1, Dec 22, 2028: Mar 4, Mar 24, Apr 13, Nov 8, Nov 27, Dec 17, More...

Pennsylvania River Cruise Departures