South Carolina River Cruise Departures

River Cruises that depart from North America: United States: South Carolina

River Cruises that visit South Carolina

See all Cruises that depart from South Carolina

Click on a cruise ship itinerary sailing from South Carolina (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South Carolina), please visit: Cruise Search or try our Virtual Cruise Advisor™.

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Related areas: Charleston

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Apr 3, Apr 17, May 1, May 15, Nov 16, Nov 30, Dec 14, Dec 28, 2027: Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, Oct 22, More...

American Cruise Lines, American Eagle

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Apr 8, Apr 22, May 6, Oct 31, Nov 14, 2027: Mar 26, Apr 9, Apr 23, May 7, Nov 1, Nov 15, 2028: Jan 28, Feb 11, Feb 25, Mar 10, Mar 24, Apr 7, Apr 21, May 5, Nov 6, Nov 20, More...

American Cruise Lines, American Legend

8 Night - Southeast Sea Islands Cruise
Starting in Charleston, SC, Day of Cruising, Beaufort, SC, Hilton Head Island, SC, Savannah, GA, Cruising Intracoastal Waterway, Jekyll Island / St Simons Island, GA, Amelia Island, FL
2026 Sails: Nov 21, Dec 5, Dec 19, 2027: Feb 3, Feb 17, Mar 3, Mar 17, Nov 29, Dec 13, Dec 27, 2028: Feb 16, Mar 1, Dec 2, Dec 16, Dec 30, More...

South Carolina River Cruise Departures