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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a river cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all river cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Related areas: Illinois : Kentucky : Louisiana : Minnesota : Missouri : Ohio : Oregon : Pennsylvania : Tennessee : Washington


American Duchess Cruises8 Night Ohio and Tennessee River Lewis and Clark Cruise from Louisville to St. Louis
Starting in Louisville; with stops in Brandenburg, KY; Owensboro, KY; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO
2019 Sails: Jul 28, More...
American Empress Cruises8 Night The Beauty and Bounty of Nature from Clarkston to Vancouver, WA
Starting in Spokane, WA; with stops in Clarkston, WA; Richland, WA; The Dalles, OR; Stevenson, WA; Astoria, OR; Vancouver, WA
2019 Sails: Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, Nov 3, More...
American Queen Cruises8 Night Upper Mississippi Mark Twain's Mississippi from Red Wing to Alton
Starting in Minneapolis, MN; with stops in Red Wing, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; Alton, IL
2019 Sails: Jul 28, More...
American Harmony Cruises7 Night Upper Mississippi River Cruise St Louis, Missouri to St Paul, Minnesota
Starting in St Louis, with stops in Hannibal, River Cruising, Davenport Iowa, Dubuque, La Crosse, Red Wing, St Paul
2019 Sails: Jul 31, 2020: Aug 28, More...
America Cruises21 Night Complete Mississippi River Cruise from New Orleans, LA to St. Paul, MN
Staring in New Orleans, LA; with stops in Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Memphis, Cape Girardeau, St. Louis, Hannibal, La Crosse, Red Wing
2019 Sails: Aug 3, 2020: Aug 6, More...
American Pride Cruises7 Nights Columbia and Snake Rivers from Portland, OR to Clarkston, WA
Starting in Portland, Oregon; with stops in Astoria, Oregon; Rainier, Oregon; Stevenson, Washington; The Dalles, Oregon; Pendleton, Oregon; Richland, Washington; Clarkston, Washington
2019 Sails: Aug 3, Aug 17, Aug 31, Sep 14, Sep 28, Oct 26, More...
American Song Cruises7 Nights Columbia and Snake Rivers from Clarkston, WA to Portland, OR
Starting in Clarkston, Washington; with stops in Pendleton, Oregon; The Dalles, Oregon; Stevenson, Washington; Rainier, Oregon; Astoria, Oregon; Portland, Oregon
2019 Sails: Aug 3, Aug 17, Aug 31, Sep 14, Nov 7, More...
American Duchess Cruises8 Night Upper Mississippi River Mark Twain's Mississippi Cruise from St. Louis to St. Paul
From St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Burlington, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2019 Sails: Aug 4, More...
American Harmony Cruises7 Night Upper Mississippi River Cruise St Paul, Minnesota to St Louis, Missouri
Starting in St Paul, with stops in Red Wing, La Crosse, Dubuque, Davenport Iowa, River Cruising, Hannibal, St Louis
2019 Sails: Aug 7, 2020: Aug 21, More...
American Duchess Cruises8 Night Upper Mississippi River Heartland Heritage Cruise Roundtrip from St. Paul
Starting in St. Paul, MN; with stops in Dubuque, IA; Prairie du Chien, WI; La Crosse, WI; Winona, MN; Red Wing, MN; St. Paul MN
2019 Sails: Aug 11, More...


United States River Cruise Departures
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