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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a river cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all river cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Related areas: Illinois : Kentucky : Louisiana : Minnesota : Missouri : Oregon : Pennsylvania : Tennessee : Washington




Queen of the West Cruises7 Night - Columbia and Snake Rivers from Portland, OR to Clarkston, WA
Starting in Portland, Oregon; with stops in Astoria, Oregon; Ranier, Oregon; Stevenson, Washington; The Dalles, Oregon; Pendleton, Oregon; Richland, Washington; Clarkston, Washington
2020 Sails: Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, Oct 19, 2021: Apr 10, Apr 24, Jul 24, Aug 21, More...
American Countess Cruises7 Night - Antebellum South from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway Plantation; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2020 Sails: Aug 2, Aug 16, Oct 4, Oct 18, Nov 15, More...
American Duchess Cruises15 Night - the Mighty Mississippi from Red Wing to New Orleans
Starting in Red Wing; with stops in Winonoa, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; Memphis; Terrene Landing, MS; Vicksburg, MS; Natchez, MS; Nottoway Plantation; New Orleans, LA
2020 Sails: Aug 2, More...
American Queen Cruises8 Night - Mark Twain's Mississippi Cruise from Red Wing to Alton
Starting in Red Wing; with stops in Winonoa, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; Alton, IL
2020 Sails: Aug 2, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from Pittsburgh, PA to St. Louis
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2020 Sails: Aug 12, 2021: Aug 20, Sep 9, Sep 29, More...
American Duchess Cruises8 Night - A Taste of the True South Lower Mississippi River Cruise from New Orleans to Memphis
Starting in New Orleans; with stops in Nottoway Plantation; St. Francisville; Natchez; Vicksburg; Memphis, TN
2020 Sails: Aug 16, Nov 1, Nov 15, Nov 29, More...
American Queen Cruises15 Night - the Mighty Mississippi from Red Wing to New Orleans
Starting in Red Wing; with stops in Winonoa, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; New Madrid, MO; St. Louis, MO; Memphis; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway Plantation; New Orleans, LA
2020 Sails: Aug 16, More...
American Harmony Cruises7 Night - Upper Mississippi River Cruise St Paul, Minnesota to St Louis, Missouri
Starting in St Paul, with stops in Red Wing, La Crosse, Dubuque, Davenport Iowa, River Cruising, Hannibal, St Louis
2020 Sails: Aug 21, More...
Queen of the Mississippi Cruises7 Night - Cumberland River Cruise from St. Louis to Nashville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN; Nashville, TN
2020 Sails: Aug 22, Sep 5, Sep 19, More...
American Countess Cruises7 Night - American River BBQ Challenge from Memphis to Alton
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO; Alton, IL
2020 Sails: Aug 23, More...


United States River Cruise Departures
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