Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Princess Cruises, Crown Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...

Norwegian Cruise Line, Norwegian Star

16 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puntarenas / Puerto Caldera, Costa Rica, Puerto Quetzal, Guatemala, Acapulco, Mexico, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Dec 4, More...

Windstar, Star Legend

16 Night - Star Collector : Windward Islands & Spanish New World
Starting in Bridgetown, Barbados, Rodney Bay, Sunset Cruising Pitons, Scarborough, Tobago, Bequia, Mayreau, St Georges, Grenada, Willemstad AN, Curacao, Oranjestad, Aruba, Cartagena CO, Bocas del Toro, San Blas Islands, Panama, Panama Canal Transit, Fuerte Amador, Panama City
2026 Sails: Dec 4, More...

Princess Cruises, Caribbean Princess

12 Night - Panama Canal with Costa Rica & Caribbean
Starting in Fort Lauderdale, Florida, Grand Cayman, Cayman Islands, Falmouth, Jamaica, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Dec 5, More...

Star Clippers, Star Clipper

14 Night - Barbados to Panama
Starting in Bridgetown, Barbados, Tobago Cays, Grenadines, St Georges, Grenada, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, Santa Marta, Colombia, Cartagena De Indias, Colombia, San Blas Archipelago, Panama, Panama Canal Transit, Balboa (Isla Flamenco), Panama
2026 Sails: Dec 5, More...

Windstar, Wind Star

7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...

Lindblad Expeditions, National Geographic Quest

7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Pearl Islands, Playa Muerto, Darien National Park, Punta Patino Nature Reserve, Balboa / Disembark Ship / Panama City, Panama
2026 Sails: Dec 6, 2028: Mar 9, More...

PONANT, Le Laperouse

12 Night - Panama, Colombia & Caribbean Islands
Starting in Fort-de-France, Marie-Galante, Pigeon Island Beach, Soufriere, Tobago Cays, Mayreau Island, Bonaire, Santa Marta, Cartagena CO, San Blas Islands, Portobelo, Colon
2026 Sails: Dec 7, More...

PONANT, Le Bellot

10 Night - Secrets of Central America
Starting in Puntarenas, Curu Wildlife Refuge, Drake Bay, Rio Esquinas, Coiba Island, Playa Muerto, Darien National Park, Pearls Islands, Pacheca Island, Crossing the Panama Canal, San Blas Islands, Fort San Lorenzo (Colon), Colon
2026 Sails: Dec 8, 2027: Jan 4, Mar 29, Dec 15, 2028: Apr 1, More...

Norwegian Cruise Line, Norwegian Sun

11 Night - Panama Canal - Miami
Starting in Miami, Fl, Falmouth, Jamaica, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Harvest Caye, Belize, Cozumel, Mexico, Miami, Fl
2026 Sails: Dec 10, 2027: Jan 2, Mar 13, More...

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